Urinary Estrogen and Progesterone Metabolite Concentrations in Menstrual Cycles of Fertile Women with Non-Conception, Early Pregnancy Loss or Clinical Pregnancy

Details

• Personal Author:
  Korrick SA ; Lasley BL ; Li Z ; Liu X ; Perry MJ ; Venners SA ; Wang X ; X ; Xu ; Yang F ; Yang J
• Description:
  Background: Knowledge is limited of how estrogen and progesterone variability in fertile women are associated with achieving pregnancy. Methods: From 1996 to 1998, we enrolled 347 textile workers without hormone treatment in Anhui, China, who provided daily urine and data upon stopping contraception for up to 1 year until clinical pregnancy. Urinary hCG was assayed to detect conception and early pregnancy losses. We compared urinary concentrations of estrone conjugates (E(1)C) and pregnanediol-3-glucuronide (PdG) in 266 clinical pregnancies, 63 early pregnancy losses and 272 non-conception cycles from 347 women and also in 94 clinical pregnancy and 94 non-conception cycles from the same women. Results: Using generalized estimating equations and relative to 266 clinical pregnancy cycles, log(E(1)C) was lower in 272 non-conception cycles [beta = -0.3 ng/mg creatinine (Cr); SE = 0.1; P < 0.0001]. On average, daily E(1)C was 18 ng/mg Cr lower in non-conception cycles than in clinical pregnancy cycles. Relative to 94 clinical pregnancy cycles, log(E(1)C) was lower in 94 non-conception cycles (beta = -0.4 ng/mg Cr; SE = 0.1; P < 0.0001) from the same women (average difference in daily E(1)C was 20 ng/mg Cr). The odds of E(1)C less than the 10th percentile (<30 ng/mg Cr) were higher in early pregnancy loss cycles [odds ratio (OR) = 4.8; P = 0.0027] than in clinical pregnancy cycles in the early luteal phase. Compared with clinical pregnancy cycles, log(PdG) concentrations were lower in non-conception cycles during the follicular phase, but this analysis lacked power for multiple testing. Conclusions: Estrogen concentrations varied from cycle to cycle, and higher estrogen was associated with achieving clinical pregnancy. [Description provided by NIOSH]
• Subjects:
  Endocrine System Energy Metabolism Estrogens Occupational Health Pregnancy Safety Textile Industry Urine Urogenital System Women Workplace

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• Keywords:
  Author Keywords: Estrogens Fertility Fertilization Hormones Humans Metabolites Progesterone Prospective Study Statistical Analysis Textiles Textile Workers Urinalysis Urine Chemistry Work Environment Workers

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• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  9
• NIOSHTIC Number:
  nn:20059669
• Citation:
  Hum Reprod 2006 Sep; 21(9):2272-2280
• Contact Point Address:
  Scott A Venners, Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL 60614, USA
• Federal Fiscal Year:
  2006
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Human Reproduction
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:94b747b8d7b208b7917d62e1773ac6df4c14b6b034df17d41d812c329c867b4aba43b6c71cb4d073df015af03177e1ab36ac371c658ce755e4335be014aee411
• Download URL:
  https://stacks.cdc.gov/view/cdc/223818/cdc_223818_DS1.pdf
• File Type:
  [PDF - 133.36 KB ]