Thyroid Hormones and Menstrual Cycle Function in a Longitudinal Cohort of Premenopausal Women

Details

• Personal Author:
  Darrow LA ; Howards PP ; Jacobson MH ; Kesner JS ; Marcus M ; Meadows JW ; Spencer JB ; Terrell ML
• Description:
  Background: Previous studies have reported that hyperthyroid and hypothyroid women experience menstrual irregularities more often compared with euthyroid women, but reasons for this are not well-understood and studies on thyroid hormones among euthyroid women are lacking. In a prospective cohort study of euthyroid women, this study characterised the relationship between thyroid hormone concentrations and prospectively collected menstrual function outcomes. Methods: Between 2004-2014, 86 euthyroid premenopausal women not lactating or taking hormonal medications participated in a study measuring menstrual function. Serum thyroid hormones were measured before the menstrual function study began. Women then collected first morning urine voids and completed daily bleeding diaries every day for three cycles. Urinary oestrogen and progesterone metabolites (estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G)) and follicle-stimulating hormone were measured and adjusted for creatinine (Cr). Results: Total thyroxine (T4) concentrations were positively associated with Pd3G and E13G. Women with higher (vs lower) T4 had greater luteal phase maximum Pd3G (Pd3G = 11.7 ug/mg Cr for women with high T4 vs Pd3G = 9.5 and 8.1 ug/mg Cr for women with medium and low T4, respectively) and greater follicular phase maximum E13G (E13G = 41.7 ng/mg Cr for women with high T4 vs E13G = 34.3 and 33.7 ng/mg Cr for women with medium and low T4, respectively). Conclusions: Circulating thyroid hormone concentrations were associated with subtle differences in menstrual cycle function outcomes, particularly sex steroid hormone levels in healthy women. Results contribute to the understanding of the relationship between thyroid function and the menstrual cycle, and may have implications for fertility and chronic disease. [Description provided by NIOSH]
• Subjects:
  Endocrine System Energy Metabolism Estrogens Occupational Health Safety Urine Women
• Keywords:
  Author Keywords: Oestrogen Euthyroid Health Effects Hormones Menstrual Cycle Function Menstrual Disorders Metabolites Progesterone Thyroid Gland Thyroid Hormones Womens Health

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• ISSN:
  0269-5022
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Nevada ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  225-234
• Volume:
  32
• Issue:
  3
• NIOSHTIC Number:
  nn:20053415
• Citation:
  Paediatr Perinat Epidemiol 2018 May; 32(3):225-234
• Contact Point Address:
  Melanie H. Jacobson, Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322
• Email:
  mhymanjacobson@emory.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Emory University, Atlanta
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Paediatric and Perinatal Epidemiology
• End Date:
  20180630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9d5a563810043958c95bf23697a24e246d431d4d7d367800780f9be96b8d06ab539901d07d7258718b952c3267f4c3f0891f9ea61227f0fab888c6c1c935517
• Download URL:
  https://stacks.cdc.gov/view/cdc/216172/cdc_216172_DS1.pdf
• File Type:
  [PDF - 348.26 KB ]