Urinary markers of ovarian aging and predicting natural fertility

Details

• Personal Author:
  Baird DD ; Herring A ; Hoberman S ; Kesner, James ; Meadows JW ; Steiner AZ
• Description:
  OBJECTIVE: To generate estimates of the association between fecundability (probability of conceiving in a menstrual cycle) and urinary markers of ovarian aging, which are used in commercial fertility tests. OBJECTIVE: To generate estimates of the association between fecundability (probability of conceiving in a menstrual cycle) and urinary markers of ovarian aging, which are used in commercial fertility tests. DESIGN: Prospective time-to-pregnancy study. MATERIALS AND METHODS: Women, 30-44 years old, with no history of infertility, who had been trying to conceive for less than 3 months, provided early follicular phase serum and urine (N=99). They were followed until pregnancy or 6 months. While trying to conceive, women conducted standardized pregnancy testing and kept a diary to record bleeding and intercourse. Urine was analyzed for follicle stimulating hormone (FSH) and estrone 3-glucuronide (E1G); levels were creatinine-corrected. Cox models were used to calculate fecundability ratios. To adjust for patterns of intercourse, diary data were used to calculate day-specific probabilities of conception. RESULTS: Serum and urinary FSH were highly correlated (r=0.85, p<0.01) as were serum estradiol and urinary E1G (r=0.78, p<0.01). Urinary FSH and E1G were not strongly associated with fecundability. CONCLUSION: Serum and urinary measures of ovarian aging are highly correlated; however, urinary creatinine-corrected early follicular phase FSH and E1G are not strongly associated with natural fertility. [Description provided by NIOSH]
• Subjects:
  Biomarkers Endocrine System Estrogens Occupational Health Pregnancy Safety Urine Urogenital System Women
• Keywords:
  Estrogenic-hormones Fertility Hormone-activity Hormones Mathematical-models Reproductive-system Urinalysis Urine-chemistry
• ISSN:
  0015-0282
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  94
• Issue:
  4
• NIOSHTIC Number:
  nn:20037732
• Citation:
  Fertil Steril 2010 Sep; 94(4)(Suppl 1):S45
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Mining
• Peer Reviewed:
  False
• Source Full Name:
  Fertility and Sterility
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d3281cc038dc54bde9b6e7d699a09b4523bc82f33cc215cbbe7cc2f6ba98bb82f7d2b1dc6b058377dde04f73326217a37180bbe0b121f3ba90ab75027f63983
• Download URL:
  https://stacks.cdc.gov/view/cdc/191719/cdc_191719_DS1.pdf
• File Type:
  [PDF - 41.67 KB ]