Preconception Serum DDT and Pregnancy Loss: A Prospective Study Using a Biomarker of Pregnancy

Details

• Personal Author:
  Altshul L ; Chen C ; Fu L ; Guang W ; Huang A ; Korrick S ; Perry M ; Venners SA ; Wang X ; Xu X
• Description:
  Previous studies of pregnancy losses and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) were limited because they did not include losses prior to clinical detection of pregnancy and because exposures were measured after the pregnancies of interest. The authors examined the association of preconception serum total DDT (sum of DDT isomers and metabolites) concentration and subsequent pregnancy losses in 388 newly married, nonsmoking, female textile workers in China between 1996 and 1998. Upon stopping contraception, subjects provided daily urine specimens and records of vaginal bleeding for up to 1 year or until clinical pregnancy. Daily urinary human chorionic gonadotropin was assayed to detect conception and early pregnancy losses, and pregnancies were followed to detect clinical spontaneous abortions. There were 128 (26%) early pregnancy losses in 500 conceptions and 36 (10%) spontaneous abortions in 372 clinical pregnancies. Subjects were grouped in tertiles by preconception serum total DDT concentration (group 1: 5.5-22.9 ng/g; group 2: 23.0-36.5 ng/g; group 3: 36.6-113.3 ng/g). Compared with group 1, group 2 had adjusted relative odds of early pregnancy losses of 1.23 (95% confidence interval (CI): 0.72, 2.10), and group 3 had adjusted odds of 2.12 (95% CI: 1.26, 3.57). The relative odds of early pregnancy losses associated with a 10-ng/g increase in serum total DDT were 1.17 (95% CI: 1.05, 1.29). The small number of spontaneous abortions following clinical detection of pregnancy were not associated with serum total DDT. In this population, there was a positive, monotonic, exposure-response association between preconception serum total DDT and the risk of subsequent early pregnancy losses. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Environmental Exposure Epidemiology Hematologic Tests Occupational Health Pregnancy Risk Assessment Risk Factors Safety Textile Industry Urine Women

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• Keywords:
  Author Keywords: Spontaneous Abortion Blood Tests Chemicals Chorionic Gonadotropin DDT Dichlorodiphenyldichloroethane Dichlorodiphenyl Dichloroethylene Dichlorodiphenyltrichloroethane Exposure Levels Health Effects Hormone Antagonists Humans Prenatal Exposure Risk Factors Statistical Analysis Textile Workers Urinalysis Urine Chemistry

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  162
• Issue:
  8
• NIOSHTIC Number:
  nn:20059665
• Citation:
  Am J Epidemiol 2005 Oct; 162(8):709-716
• Contact Point Address:
  Dr. Xiaobin Wang, Mary Ann and J. Milburn Smith Child Health Research Program, Children's Memorial Hospital, 2300 Children's Plaza, Box 157, Chicago, IL 60614
• Email:
  xbwang@childrensmemorial.org
• Federal Fiscal Year:
  2006
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:448364a37b8de2d07a5e4822fd51575f46edf12a046ec8f9e0b6024e4aeb5f056bb4cd0bc9818182d4c51c1c7e1c459990124f4572fbe0fde8534f35adbe931e
• Download URL:
  https://stacks.cdc.gov/view/cdc/223814/cdc_223814_DS1.pdf
• File Type:
  [PDF - 126.40 KB ]