Maternal Exposure to Second-Hand Tobacco Smoke and Pregnancy Outcome Among Couples Undergoing Assisted Reproduction

Details

• Personal Author:
  Cramer DW ; Hauser R ; Meeker JD ; Missmer SA
• Description:
  BACKGROUND: Exposure to second-hand tobacco smoke is preventable, yet common. This study assessed relationships between maternal exposure to second-hand tobacco smoke and adverse pregnancy outcomes. METHODS: We measured cotinine (a biomarker of tobacco smoke) in urine from 921 women undergoing assisted reproductive technologies (ARTs) between 1994 and 1998. We also collected information on self-reported exposure to second-hand smoke at home or at work, in addition to parental smoking during the women's childhood. RESULTS: In crude analysis, creatinine-adjusted cotinine levels were associated with a slight decrease in implantation rate among non-smoking women (11.1% in the lowest cotinine quintile versus 8.2% in the highest cotinine quintile; P = 0.13). However, in multivariate logistic regression, cotinine levels above the median were not associated with failed fertilization, failed implantation or spontaneous abortion, nor was there evidence of a dose response relationship among cotinine quintiles. After excluding women in couples diagnosed with male factor infertility, there were increased odds of having a spontaneous abortion among non-smoking women who reported that both parents smoked while they were children growing up compared with women reporting that neither parent smoked adjusted odds ratio (OR) = 4.35; 95% confidence interval (CI) = 1.04-18.1. CONCLUSIONS: Female exposure to second-hand smoke as a child or in utero may be associated with an increased risk of spontaneous abortion in adulthood. However, this may be a chance finding due to multiple comparisons. Similar associations should be explored in additional studies with more refined estimates of childhood and in utero exposure to tobacco smoke. Description provided by NIOSH
• Subjects:
  • Biomarkers
  • Environmental Exposure
  • Occupational Health
  • Pregnancy
  • Risk Assessment
  • Risk Factors
  • Safety
  • Smoke
  • Smokers
  • Tobacco Products
  More +
• Keywords:
  • Humans
  • Women
  • Pregnancy
  • Prenatal exposure
  • Exposure levels
  • Risk factors
  • Tobacco smoke
  • Tobacco
  • Smoking
  • Secondhand smoke
  More +
• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  337-345
• Volume:
  22
• Issue:
  2
• NIOSHTIC Number:
  nn:20058434
• Citation:
  Hum Reprod 2007 Feb; 22(2):337-345
• Contact Point Address:
  J.D.Meeker, Department of Environmental Health Sciences, University of Michigan School of Public Health, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Human Reproduction
• End Date:
  20280630
• Download URL:
  https://stacks.cdc.gov/view/cdc/221526/cdc_221526_DS1.pdf
• File Type:
  [PDF - 121.60 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c73cf3959c166878ed80c49e86ca00de836ed8eb89f6b975724ee7e8bddfd1a7d938ad597fbb75ce636ff7c6c1c361aad95d51ba40ce69e900e783032214c1e