Maternal Exposure to Second-Hand Tobacco Smoke and Pregnancy Outcome Among Couples Undergoing Assisted Reproduction

Details

• Personal Author:
  Cramer DW ; Hauser R ; Meeker JD ; Missmer SA
• Description:
  BACKGROUND: Exposure to second-hand tobacco smoke is preventable, yet common. This study assessed relationships between maternal exposure to second-hand tobacco smoke and adverse pregnancy outcomes. METHODS: We measured cotinine (a biomarker of tobacco smoke) in urine from 921 women undergoing assisted reproductive technologies (ARTs) between 1994 and 1998. We also collected information on self-reported exposure to second-hand smoke at home or at work, in addition to parental smoking during the women's childhood. RESULTS: In crude analysis, creatinine-adjusted cotinine levels were associated with a slight decrease in implantation rate among non-smoking women (11.1% in the lowest cotinine quintile versus 8.2% in the highest cotinine quintile; P = 0.13). However, in multivariate logistic regression, cotinine levels above the median were not associated with failed fertilization, failed implantation or spontaneous abortion, nor was there evidence of a dose response relationship among cotinine quintiles. After excluding women in couples diagnosed with male factor infertility, there were increased odds of having a spontaneous abortion among non-smoking women who reported that both parents smoked while they were children growing up compared with women reporting that neither parent smoked [adjusted odds ratio (OR) = 4.35; 95% confidence interval (CI) = 1.04-18.1]. CONCLUSIONS: Female exposure to second-hand smoke as a child or in utero may be associated with an increased risk of spontaneous abortion in adulthood. However, this may be a chance finding due to multiple comparisons. Similar associations should be explored in additional studies with more refined estimates of childhood and in utero exposure to tobacco smoke. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Occupational Health Pregnancy Risk Assessment Risk Factors Safety Smoke Smokers Tobacco Products Urine Women

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• Keywords:
  Author Keywords: ETS Exposure Levels Humans IVF Prenatal Exposure Risk Factors Second-hand Smoke Secondhand Smoke Smoking Spontaneous Abortion Statistical Analysis Tobacco Tobacco Smoke Urinalysis Urine Chemistry

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• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  337-345
• Volume:
  22
• Issue:
  2
• NIOSHTIC Number:
  nn:20058434
• Citation:
  Hum Reprod 2007 Feb; 22(2):337-345
• Contact Point Address:
  J.D.Meeker, Department of Environmental Health Sciences, University of Michigan School of Public Health, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Human Reproduction
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c73cf3959c166878ed80c49e86ca00de836ed8eb89f6b975724ee7e8bddfd1a7d938ad597fbb75ce636ff7c6c1c361aad95d51ba40ce69e900e783032214c1e
• Download URL:
  https://stacks.cdc.gov/view/cdc/221526/cdc_221526_DS1.pdf
• File Type:
  [PDF - 121.60 KB ]