Microenvironmental Alterations in Carbon Nanotube-Induced Lung Inflammation and Fibrosis

Details

• Personal Author:
  Dong J
• Description:
  Carbon nanotube (CNT)-induced pulmonary inflammation and fibrosis have been intensively observed and characterized in numerous animal studies in the past decade. Remarkably, CNT-induced fibrotic lesions highly resemble some human fibrotic lung diseases, such as IPF and pneumoconiosis, regarding disease development and pathological features. This notion leads to a serious concern over the health impact of CNTs in exposed human populations, considering the rapidly expanding production of CNT materials for diverse industrial and commercial applications, and meanwhile provides the rationale for exploring CNT-induced pathologic effects in the lung. Accumulating mechanistic understanding of CNT lung pathology at the systemic, cellular, and molecular levels has demonstrated the potential of using CNT-exposed animals as a new disease model for the studies on inflammation, fibrosis, and the interactions between these two disease states. Tissue microenvironment plays critical roles in maintaining homeostasis and physiological functions of organ systems. When aberrant microenvironment forms under intrinsic or extrinsic stimulation, tissue abnormality, organ dysfunction, and pathological outcomes are induced, resulting in disease development. In this article, the cellular and molecular alterations that are induced in tissue microenvironment and implicated in the initiation and progression of inflammation and fibrosis in CNT-exposed lungs, including effector cells, soluble mediators, and functional events exemplified by cell differentiation and extracellular matrix (ECM) modification, are summarized and discussed. This analysis would provide new insights into the mechanistic understanding of lung inflammation and fibrosis induced by CNTs, as well as the development of CNT-exposed animals as a new model for human lung diseases. [Description provided by NIOSH]
• Subjects:
  Immune System Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Author Keywords: Inflammation Carbon Nanotube Carbon Nanotubes Cellular Effects CNT Effector Cell Extracellular Matrix Fibrosis Immune Reaction Lung Disease Lung Fibrosis Nanotechnology Nanotoxicology Soluble Factor Tissue Culture

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• ISSN:
  2296-634X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• NIOSHTIC Number:
  nn:20059182
• Citation:
  Front Cell Dev Biol 2020 Feb; 8:126
• Contact Point Address:
  Jie Dong, Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, United States
• Email:
  wyo6@cdc.gov
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Cell and Developmental Biology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c596b5bcc64765e45f5274308e684adef70e724d4e4abe7e6f7fc1d23deb77b8d6268bd10501d4030e28385e7d06db5d2fdf8c6314d72e7c40ab49186b3dc51b
• Download URL:
  https://stacks.cdc.gov/view/cdc/223477/cdc_223477_DS1.pdf
• File Type:
  [PDF - 268.65 KB ]