Signaling Pathways Implicated in Carbon Nanotube-Induced Lung Inflammation

Details

• Personal Author:
  Dong J
• Description:
  Inflammation is a tissue response to a variety of harmful stimuli, such as pathogens, irritants, and injuries, and can eliminate insults and limit tissue damage. However, dysregulated inflammation is recognized as a cause of many human diseases, exemplified by organ fibrosis and cancer. In this regard, inflammation-promoted fibrosis is commonly observed in human lung diseases, such as idiopathic pulmonary fibrosis and pneumoconiosis. Carbon nanotubes (CNTs) are a type of nanomaterials with unique properties and various industrial and commercial applications. On the other hand, certain forms of CNTs are potent inducers of inflammation and fibrosis in animal lungs. Notably, acute inflammation is a remarkable phenotype elicited by CNTs in the lung during the early acute phase post-exposure; whereas a type 2 immune response is evidently activated and dominates during the late acute and chronic phases, leading to type 2 inflammation and lung fibrosis. Numerous studies demonstrate that these immune responses involve distinct immune cells, various pathologic factors, and specific functions and play crucial roles in the initiation and progression of inflammation and fibrosis in the lung exposed to CNTs. Thus, the mechanistic understanding of the immune responses activated by CNTs has drawn great attention in recent years. This article reviews the major findings on the cell signaling pathways that are activated in immune cells and exert functions in promoting immune responses in CNT-exposed lungs, which would provide new insights into the understanding of CNT-induced lung inflammation and inflammation-driven fibrosis, the application of CNT-induced lung inflammation and fibrosis as a new disease model, and the potential of targeting immune cells as a therapeutic strategy for relevant human lung diseases. [Description provided by NIOSH]
• Subjects:
  Fibrosis Immune System Lung Diseases Occupational Health Pathology Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Author Keywords: Inflammation Carbon Nanotube Carbon Nanotubes Cell Signaling Cellular Effects CNT Immune Cell Immune System Lung Disease Nanotechnology Nanotoxicology Signaling Pathway Transcription Factor Type 2 Immune Response

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• ISSN:
  1664-3224
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20061812
• Citation:
  Front Immunol 2020 Dec; 11:552613
• Contact Point Address:
  Jie Dong, Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, United States
• Email:
  wyo6@cdc.gov
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c5251c27563af23e4e171b41448fa534ff8edff1a89ac9694805a2de91386847b4615501cbc14d6a4b43c9645965bf337943685c30a977d3e16426aff5454f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/225189/cdc_225189_DS1.pdf
• File Type:
  [PDF - 3.76 MB ]