Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary Intervention

Details

• Personal Author:
  Nolan A
• Description:
  We validated the utility of MetSyn-defining biomarkers in predicting the development of WTC-LI (AIM 1), published and presented findings relevant to the hypotheses of AIM 2, incorporated preliminary data developed in the first funding period in ALL AIMs, and completed enrollment for our FIREHOUSE RCT (AIM 3). Research Outcomes/Impact. Fire Department of New York (FDNY) rescue/recovery workers exposed to World Trade Center (WTC) particulate matter (PM) developed lung disease and continue to have their health and well-being adversely affected. We have discovered that biomarkers of metabolic syndrome (MetSyn) and vascular injury not only predict but are also modifiable risks of developing WTC-Lung Injury (WTC-LI). Our recent study's associated editorial stated "The time has come to think of MetSyn not only as a cardiovascular risk factor, but also as a modifiable pulmonary one..." Our body of work fits into the broader literature that explores the association of poor metabolic health and lung disease in those exposed to pollution. Although the mechanisms that lead pollution and MetSyn to lung disease remain poorly understood, they are an area of active investigation as part of the mandates of the James Zadroga 9/11 Health and Compensation Act. We also successfully completed our proof of concept Fat Intake REstriction for Health Outcome Support and Education (FIREHOUSE) RCT: a technology supported nutritional intervention comparing a low calorie Mediterranean type diet(LoCalMed) to usual care(UC). [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Emergency Responders Energy Metabolism Firefighters Lung Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Cohort Studies Dietary Effects Disaster Recovery Emergency Responders Fire Fighters First Responders Longitudinal Study Lung Function Metabolic Effects Metabolites Rescue Workers World Trade Center WTC

  More +
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-23
• NIOSHTIC Number:
  nn:20066254
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011300, 2022 Sep; :1-23
• Email:
  anna.nolan@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1f39d3af03ebdd7eb6fd1c352288bc7aee76d2a7f0e1a3049a84488b360ad8a1580569854a65f4122747dbbddb02bf51d1fcd84e891a735e1dc2af6ecb98070f
• Download URL:
  https://stacks.cdc.gov/view/cdc/219151/cdc_219151_DS1.pdf
• File Type:
  [PDF - 710.13 KB ]