Boundary Cases for Bayesian Benchmark Dose Analysis

Details

• Personal Author:
  Wheeler M ; Wheeler M
• Description:
  In this demonstration, a case study on unanticipated results when applying Bayesian methods to dose-response analyses and benchmark dose estimation is studied. This presentation will discuss advanced considerations in BMD modeling such as model boundary conditions, priors, and flexibility. Specifically, this talk will investigate a dataset where traditional maximum likelihood methods produce unstable estimates and noninformative Bayesian analysis produces results that are not intuitive. The focus will be on the impact of prior selection on results and the importance of conducting sensitivity analysis. Means for integrating toxicological knowledge into priors for Bayesian approaches in BMD analyses will be discussed. [Description provided by NIOSH]
• Subjects:
  Case Reports Environmental Exposure Hazardous Substances Occupational Health Risk Assessment Risk Factors Safety Toxicology
• Keywords:
  Algorithms Analytical Models Case Studies Chemical Hazards Data Processing Dose Response Exposure Levels Hazards Mathematical Models Models Qualitative Analysis Risk Analysis Risk Assessment Risk Factors Sensitivity Testing Statistical Analysis Statistical Quality Control Toxins

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration ; DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  174
• Issue:
  1
• NIOSHTIC Number:
  nn:20058916
• Citation:
  Toxicologist 2020 Mar; 174(1):177
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 59th Annual Meeting and ToxExpo, March 15-19, 2020, Anaheim, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:af13d2062b3a8cf8359fe5ac97d4c8c54b43f67e2693a2575cf6a503c24e3004c41d86bb6356486a7143ab7f03927d546753e38cc9b299bdcdc6faed21ee0a58
• Download URL:
  https://stacks.cdc.gov/view/cdc/223275/cdc_223275_DS1.pdf
• File Type:
  [PDF - 521.44 KB ]