Bring Harmonization into Dose-Response and Benchmark Dose Modeling Guidance

Details

• Personal Author:
  Wheeler M
• Description:
  To establish a point of departure, some form of dose-response analysis (DRA) must be employed. Benchmark dose (BMD) modeling is the preferred approach over the NOAEL/LOAEL approach for a number of reasons, as identified by the WHO risk assessment guidance EHC 240. However, there are myriad choices available to the modeler, which range from the form of the dose-response curve to the type of analysis (e.g., frequentist versus Bayesian versus model average), and the question becomes, How does one make reproducible, scientifically valid decisions with all of these options? To bring harmonization and transparency into BMD modeling, the new guidance addresses these discrepancies by emphasizing the use of multi-model inference using model averaging, with a reliance on Bayesian models to implement "soft-constraints" on model parameters. The speaker will focus on how the newly developed guidance leverages new methodologies (e.g., model averaging and Bayesian dose-response modeling) while producing scientifically sound and robust results. Emphasis is made on the selection of different model suite and Bayesian priors for proper analyses of the BMD. This talk is geared toward toxicologists and BMD software users. It focuses on the practical choices when performing a dose-response analysis and is not intended to be technical in nature. [Description provided by NIOSH]
• Subjects:
  Decision Making Occupational Health Risk Assessment Safety Toxicology
• Keywords:
  Analytical Models Analytical Processes Data Processing Decision Making Dose Response Guidelines Mathematical Models Models Risk Analysis Risk Assessment Standards Statistical Quality Control

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  174
• Issue:
  1
• NIOSHTIC Number:
  nn:20059004
• Citation:
  Toxicologist 2020 Mar; 174(1):172
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 59th Annual Meeting and ToxExpo, March 15-19, 2020, Anaheim, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d83bee166267313bfae48b9b9bbea822e4b87e694b69b55dae6ced7e03b1c6f3e465cdf8e7b4772ecafd5b77794e2764a0c560e1d05e100a308406ce3596b3b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/223343/cdc_223343_DS1.pdf
• File Type:
  [PDF - 522.03 KB ]