Serum DDT, Age at Menarche, and Abnormal Menstrual Cycle Length

Details

• Personal Author:
  Chen C ; Fang Z ; Ouyang F ; Perry MJ ; Venners SA ; Wang B ; Wang L ; Wang X ; Xu X ; Yang F ; Zang T
• Description:
  Background: Although dichlorodiphenyl trichloroethane (DDT) exposure is known to affect human endocrine function, few previous studies have investigated the effects of DDT exposure on age at menarche or menstrual cycle length. Methods: A cross sectional study was conducted to study the effects of DDT exposure on age at menarche and menstrual cycle length among 466 newly married, nulliparous female Chinese textile workers aged 20-34 years enrolled between 1996 and 1998. Serum was analysed for DDT and its major metabolites. Multivariate linear regression was used to estimate DDT exposure effects on age at menarche and multivariate logistic regression was used to estimate DDT exposure effects on odds of experiencing short or long cycles. Results: Relative to those in the lowest DDT quartile, the adjusted mean age at menarche was younger in those in the fourth quartile (-1.11 years). Modeled as a continuous variable, a 10 ng/g increase in serum DDT concentration was associated with an adjusted reduction in age at menarche of 0.20 years. Relative to those in the lowest DDT quartile, odds of any short cycle (<21 days) in the previous year were higher for those in the fourth quartile (odds ratio = 2.78; 95% CI 1.07 to 7.14). There were no associations between serum DDT concentrations and odds of experiencing a long cycle (>40 days). Conclusion: Results suggest that DDT exposure was associated with earlier age at menarche and increased risk of experiencing a shortened menstrual cycle. [Description provided by NIOSH]
• Subjects:
  Endocrine System Occupational Health Safety Women
• Keywords:
  DDT Dichlorodiphenyltrichloroethane Endocrine Disruptors Endocrine System Exposure Assessment Menstrual Disorders
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  62
• Issue:
  12
• NIOSHTIC Number:
  nn:20058740
• Citation:
  Occup Environ Med 2005 Dec; 62(12):878-884
• Contact Point Address:
  Dr M Perry, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 1413, Boston, MA 02115, USA
• Email:
  mperry@hsph.harvard.edu
• CAS Registry Number:
  DDT (CAS RN 50-29-3)
• Federal Fiscal Year:
  2006
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5312b7514e3022eabfa269e9b9c3e6b3b2820d5e88d315dce2b3640c31afc25170abe03d32da3ef1742209613638997f6ba72aae7803f88d733dc9e6f3d1fd1
• Download URL:
  https://stacks.cdc.gov/view/cdc/223140/cdc_223140_DS1.pdf
• File Type:
  [PDF - 94.64 KB ]