Detecting associations between early-life DDT exposures and childhood growth patterns: a novel statistical approach

Details

• Personal Author:
  Eskenazi B ; Harley K ; Heggeseth B ; Jewell N ; Warner M
• Description:
  It has been hypothesized that environmental exposures at key development periods such as in utero play a role in childhood growth and obesity. To investigate whether in utero exposure to endocrine-disrupting chemicals, dichlorodiphenyltrichloroethane (DDT) and its metabolite, dichlorodiphenyldichloroethane (DDE), is associated with childhood physical growth, we took a novel statistical approach to analyze data from the CHAMACOS cohort study. To model heterogeneity in the growth patterns, we used a finite mixture model in combination with a data transformation to characterize body mass index (BMI) with four groups and estimated the association between exposure and group membership. In boys, higher maternal concentrations of DDT and DDE during pregnancy are associated with a BMI growth pattern that is stable until about age five followed by increased growth through age nine. In contrast, higher maternal DDT exposure during pregnancy is associated with a flat, relatively stable growth pattern in girls. This study suggests that in utero exposure to DDT and DDE may be associated with childhood BMI growth patterns, not just BMI level, and both the magnitude of exposure and sex may impact the relationship. [Description provided by NIOSH]
• Subjects:
  Endocrine System Insecticides Occupational Health Safety Sex Characteristics
• Keywords:
  Children DDT Dichlorodiphenyltrichloroethane Endocrine Disruptors Endocrine System Disorders Gender Factors In Utero Exposure Pesticide Residues Pesticides Pesticides And Agricultural Chemicals Statistical Analysis

  More +
• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; OSHA Region 1 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• Issue:
  6
• NIOSHTIC Number:
  nn:20047773
• Citation:
  PLoS One 2015 Jun; 10(6):e0131443
• Contact Point Address:
  Brianna Heggeseth, Department of Mathematics and Statistics, Williams College, Williamstown, MA, USA
• Email:
  Brianna.c.Heggeseth@williams.edu
• CAS Registry Number:
  DDT (CAS RN 50-29-3) ; p,p′-DDD (CAS RN 72-54-8) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  PLoS One
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00bc8e1ece7888abd7ad4f27dc29c19a72fe342c97b9f50d9ada356ccdc736a6e056863d2c3ff540666136ab724511498f4c901128a8e30d8a1640f4b2f7271f
• Download URL:
  https://stacks.cdc.gov/view/cdc/202756/cdc_202756_DS1.pdf
• File Type:
  [PDF - 414.66 KB ]