Carcinogenicity of 1,1, 1-Trichloroethane and Four Other Industrial Chemicals

Details

• Personal Author:
  Audebert M ; Belpoggi F ; Benbrahim-Tallaa L ; Cattley RC ; Cox J ; de Conti A ; DeBono NL ; El Ghissassi F ; Ge C ; Goodman S ; Grosse Y ; Gustavsson P ; Gwinn W ; Käfferlein H ; Kühnle S ; Lash L ; Lavoué J ; Lumen A ; Matsumoto M ; Mattock H ; Middleton DRS ; Miranda-Filho A ; Muñoz-Quezada MT ; Onyije FM ; Peters C ; Purdue M ; Reisfeld B ; Schubauer-Berigan, Mary K. ; Stewart P ; Suonio E ; Svendsen C ; Turner MC ; Viegas S ; Virji, M. Abbas ; Wedekind R ; Yakubovskaya MG ; Yiin J
• Corporate Authors:
  World Health Organization. International Agency for Research on Cancer. Monographs Priorities Group
• Description:
  In October, 2021, a Working Group of 20 scientists from 12 countries met remotely at the invitation of the International Agency for Research on Cancer (IARC) to finalise their evaluation of the carcinogenicity of five agents: 1,1,1-trichloroethane, 1,2-diphenylhydrazine, diphenylamine, N-methylolacrylamide, and isophorone. These assessments will be published in Volume 130 of the IARC Monographs. 1,1,1-Trichloroethane was classified as "probably carcinogenic to humans" (Group 2A) on the basis of "limited" evidence of carcinogenicity in humans and "sufficient" evidence in experimental animals. All other agents were classified as "possibly carcinogenic to humans" (Group 2B) on the basis of "sufficient" evidence of carcinogenicity in experimental animals. The evidence for carcinogenicity in experimental animals was "sufficient" because all agents, except N-methylolacrylamide, increased the incidence of malignant neoplasms or an appropriate combination of benign and malignant neoplasms in two species. N-Methylolacrylamide caused the aforementioned increase in both sexes of a single species in a Good Laboratory Practice (GLP) study. Evidence regarding cancer in humans was "inadequate" for agents other than 1,1,1-trichlorethane because few or no data were available. For all agents, the mechanistic evidence was "limited". [Description provided by NIOSH]
• Subjects:
  Carcinogens Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Cancer Carcinogen Policy Chemicals Occupational Exposure Recommendations
• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OECSP - Office of Extramural Coordination and Special Projects ; WTCHP - World Trade Center Health Program
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  12
• NIOSHTIC Number:
  nn:20064518
• Citation:
  Lancet Oncol 2021 Dec; 22(12):1661-1662
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; Diphenylamine (CAS RN 122-39-4) ; Hydrazobenzene (CAS RN 122-66-7) ; Isophorone (CAS RN 78-59-1) ; N-Methylolacrylamide (CAS RN 924-42-5)
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:12c5072850f761f992b37617e79f2cfe5c014b39bd44232b6815261b07041bfb5a868d8749b64ca992d1ed5b5dc738d657f95be09c7e2a711becc6fb8ff8cfd9
• Download URL:
  https://stacks.cdc.gov/view/cdc/222966/cdc_222966_DS1.pdf
• File Type:
  [PDF - 47.37 KB ]