Carcinogenicity of Aspartame, Methyleugenol, and Isoeugenol

Details

• Personal Author:
  Afghan A ; Assunção R ; Beland FA ; Benbrahim-Tallaa L ; Caderni G ; Chittiboyina S ; Corton JC ; Cuomo D ; de Aragão Umbuzeiro G ; de Conti A ; de Jong D ; DeBono NL ; Debras C ; Deschasaux-Tanguy M ; El Ghissassi F ; Fontvieille E ; Harewood R ; Hodge A ; Ishihara J ; Kaldor J ; Lachenmeier DW ; Levy DD ; Madia F ; Mandrioli D ; Marques MM ; Mattock H ; McCullough ML ; McNaughton SA ; Morita T ; Nugent AP ; Ogawa K ; Pandiri AR ; Pasqual E ; Phillips DH ; Riboli E ; Rigutto G ; Schernhammer E ; Schubauer-Berigan, Mary K. ; Sergi CM ; Simba H ; Suonio E ; Touvier M ; Viegas S ; Wedekind R ; Zhang L
• Description:
  In June, 2023, a Working Group of 25 scientists from 12 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of aspartame, methyleugenol, and isoeugenol. Aspartame was classified as "possibly carcinogenic to humans" (Group 2B) based on "limited" evidence for cancer in humans. There was also "limited" evidence for cancer in experimental animals and "limited" mechanistic evidence. Methyleugenol was classified as "probably carcinogenic to humans" (Group 2A) based on "sufficient" evidence for cancer in experimental animals and "strong" mechanistic evidence, including studies in humanised mice and supported by mechanistic studies in exposed humans. Isoeugenol was classified as "possibly carcinogenic to humans" (Group 2B) based on "sufficient" evidence for cancer in experimental animals. For both methyleugenol and isoeugenol, the evidence regarding cancer in humans was "inadequate", as no epidemiological studies were available. These assessments will be published in Volume 134 of the IARC Monographs.1 Immediately following IARC's meeting on cancer hazard identification, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) conducted a risk assessment exercise, including a review of the acceptable daily intake of aspartame. A summary of these results has been published. [Description provided by NIOSH]
• Subjects:
  Carcinogens Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Cancer Carcinogen Policy Chemicals Occupational Exposure Recommendations
• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  8
• NIOSHTIC Number:
  nn:20069132
• Citation:
  Lancet Oncol 2023 Aug; 24(8):848-850
• CAS Registry Number:
  Aspartame (CAS RN 22839-47-0) ; Isoeugenol (CAS RN 97-54-1) ; Methyleugenol (CAS RN 93-15-2)
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  True
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e9c491597b6e36e4c8f7527cb294e41e90fc63dc06a973052aced37783ade87c41263964b25d6951568993ca33d04dae92e36f83229fac549fb02a8e38f7b62f
• Download URL:
  https://stacks.cdc.gov/view/cdc/207669/cdc_207669_DS1.pdf
• File Type:
  [PDF - 148.04 KB ]