Depression and Anxiety in a Manganese-Exposed Community

Details

• Personal Author:
  Checkoway, Harvey ; Dlamini WW ; Hershey T ; Nelson G ; Prathibha P ; Racette BA ; Searles Nielsen S ; Sheppard L ; Turner JR
• Description:
  Objective: To characterize the association between residential environmental manganese (Mn) exposure and depression and anxiety, given prior associations among occupationally-exposed workers. Methods: We administered the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) to 697 study participants in their preferred languages. These participants represented a population-based sample of residents aged >=40 from two predominantly Black African communities in Gauteng province, South Africa: 605 in Meyerton, adjacent to a large Mn smelter, and 92 in Ethembalethu, a comparable non-exposed community. We investigated the associations between community (Meyerton vs. Ethembalethu) and severity of depression and anxiety, using linear regression, adjusting for age and sex. To document community-level differences in Mn exposure, we measured airborne PM2.5-Mn. Results: Meyerton residents had BDI scores 5.63 points (95 % CI 3.07, 8.20) higher than Ethembalethu residents, with all questions contributing to this significant difference. STAI-state scores were marginally higher in Meyerton than Ethembalethu residents [2.12 (95 % CI -0.17, 4.41)], whereas STAI-trait scores were more similar between the communities [1.26 (95 % CI -0.82, 3.35)]. Mean PM2.5-Mn concentration was 203 ng/m3 at a long-term fixed site in Meyerton and 10 ng/m3 in Ethembalethu. Conclusion: Residence near Mn emission sources may be associated with greater depression symptomatology, and possibly current, but not lifetime, anxiety. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollutants, Occupational Epidemiology Manganese Men Mental Health Nervous System Occupational Health Particulate Matter Race Factors Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Age Groups Airborne Particles Airborne Particulates Author Keywords: Beck Depression Inventory Chemicals Health Effects Humans Neurotoxic Effects Neurotoxicity PM2.5-Mn Psychological Effects Psychological Reactions Psychology Racial Factors Risk Factors South Africa State-trait Anxiety Inventory Work Environment Workers

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Missouri ; OSHA Region 10 ; OSHA Region 7 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  222-233
• Volume:
  85
• NIOSHTIC Number:
  nn:20064458
• Citation:
  Neurotoxicology 2021 Jul; 85:222-233
• Contact Point Address:
  Brad A. Racette, Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110
• Email:
  racetteb@wustl.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of California, San Diego
• Peer Reviewed:
  True
• Start Date:
  20190801
• Source Full Name:
  Neurotoxicology
• End Date:
  20230731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:236a2d3a4ac6a9f2ba3ad05bdb98616ff4467ba996c18579423f9d18d157f12fcc44155b0b533da229bbb40528782e28c87c59d16ccf23043beac1c7591fb4e9
• Download URL:
  https://stacks.cdc.gov/view/cdc/222912/cdc_222912_DS1.pdf
• File Type:
  [PDF - 967.78 KB ]