In Vivo Neutron Activation Analysis of Bone Manganese in Workers

Details

• Personal Author:
  Li Y ; Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells E ; Zheng W ; Zhou Y
• Description:
  Manganese (Mn) is a neurotoxicant. However, the impact of elevated, chronic Mn exposure is not well understood, partially due to the lack of a cumulative exposure biomarker. To address this gap, our group developed a compact in vivo neutron activation analysis (IVNAA) system to quantify Mn in bone (MnBn). In this study, we used this system and determined MnBn among male Chinese workers and compared results to their blood Mn (MnB), a measure of recent exposure, and the years of employment, a measure of cumulative exposure. A cross-sectional study was conducted with 30 ferroalloy smelters (exposed) and 30 general manufacturing workers (controls). MnBn was assessed using IVNAA, MnB was measured with inductively coupled plasma mass spectrometry, and occupational history and demographics were obtained via questionnaire. Mn-doped phantoms were used to generate a calibration curve; spectra from these phantoms were consistent with in vivo spectra. Median [interquartile range (IQR)] values for Mn biomarkers were 2.7 ug/g (7.2) for MnBn and 14.1 ug/L (4.0) for MnB. In regression models adjusted for age and education, the natural log transformed MnBn [ln(MnBn)] was significantly associated with the exposed/control status (beta=0.44, p=0.047) and years of employment (beta=0.05, p=0.002), but not with natural log transformed MnB[ln(MnB)] (beta=0.54, p=0.188). Our results support the use of IVNAA to quantify MnBn and the use of MnBn as a biomarker of cumulative Mn exposure. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Demography Education Environmental Exposure Hematologic Tests Manganese Men Nervous System Occupational Health Race Factors Risk Assessment Risk Factors Safety Surveys And Questionnaires

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• Keywords:
  Age Groups Author Keywords: Manganese Blood Samples Bone Bone Structure Demographic Characteristics Exposure Levels Humans Mass Spectrometry Mn Models NAA Neurotoxic Effects Neurotoxins Neutron Activation Analysis Questionnaires Racial Factors Risk Factors Sociological Factors Workers

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• ISSN:
  0967-3334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• NIOSHTIC Number:
  nn:20050908
• Citation:
  Physiol Meas 2018 Mar; 39:035003
• Contact Point Address:
  Linda H. Nie, School of Health Sciences, Purdue University, West Lafayette, Indiana 47906
• Email:
  hnie@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  Physiological Measurement
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:33765d2653cc7c031a665a967635bc261eee8b1661a1dfdc628d383019cc283300f2d7ccf096c93a183ac4eaaa198637b2f5562aa4e37a69b4ee387166dd095e
• Download URL:
  https://stacks.cdc.gov/view/cdc/211094/cdc_211094_DS1.pdf
• File Type:
  [PDF - 766.63 KB ]