Associations of welding and manganese exposure with Parkinson disease: review and meta-analysis

Details

• Personal Author:
  Borenstein AR ; Mortimer JA ; Nelson LM
• Description:
  OBJECTIVE: To examine associations of welding and manganese exposure with Parkinson disease (PD) using meta-analyses of data from cohort, case-control, and mortality studies. METHODS: Epidemiologic studies related to welding or manganese exposure and PD were identified in a PubMed search, article references, published reviews, and abstracts. Inclusion criteria were 1) cohort, case-control, or mortality study with relative risk (RR), odds ratio (OR), or mortality OR (MOR) and 95 confidence intervals (95% CI); 2) RR, OR, and MOR matched or adjusted for age and sex; 3) valid study design and analysis. When participants of a study were a subgroup of those in a larger study, only results of the larger study were included to assure independence of datasets. Pooled RR/OR estimates and 95% CIs were obtained using random effects models; heterogeneity of study effects were evaluated using the Q statistic and I(2) index in fixed effect models. RESULTS: Thirteen studies met inclusion criteria for the welding meta-analysis and 3 studies for the manganese exposure meta-analysis. The pooled RR for the association between welding and PD for all study designs was 0.86 (95% CI 0.80-0.92), with absence of between-study heterogeneity (I(2) = 0.0). Effect measures for cohort, case-control, and mortality studies were similar (0.91, 0.82, 0.87). For the association between manganese exposure and PD, the pooled OR was 0.76 (95% CI 0.41-1.42). CONCLUSIONS: Welding and manganese exposure are not associated with increased PD risk. Possible explanations for the inverse association between welding and PD include confounding by smoking, healthy worker effect, and hormesis. [Description provided by NIOSH]
• Subjects:
  Aging Epidemiology Hazardous Substances Manganese Men Nervous System Occupational Health Risk Assessment Risk Factors Safety Smokers Welding Women

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• Keywords:
  Age-groups Etiology Exposure-levels Humans Manganese-compounds Neuromuscular-function Risk-factors Smoking Statistical-analysis Toxic-effects
• ISSN:
  0028-3878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Florida ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  79
• Issue:
  11
• NIOSHTIC Number:
  nn:20041900
• Citation:
  Neurology 2012 Sep; 79(11):1174-1180
• Email:
  jmortime@health.usf.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Stanford University
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  Neurology
• End Date:
  20130831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a5586602d706533098dd0d577675302267229f20277d22c614f8b1334653f0c0bd88931adf3604e3386201e2a4f70991d2c7ffc54b9c710b8fe9e2654cc8831
• Download URL:
  https://stacks.cdc.gov/view/cdc/194323/cdc_194323_DS1.pdf
• File Type:
  [PDF - 337.85 KB ]