High Rates of Antimicrobial Drug Resistance Gene Acquisition after International Travel, the Netherlands

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  von Wintersdorff, Christian J.H. ; Penders, John ; Stobberingh, Ellen E. ; Lashof, Astrid M.L. Oude ; Hoebe, Christian J.P.A. ; Savelkoul, Paul H.M. ; Wolffs, Petra F.G.
• Description:
  We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both blaCTX-M and qnrS, respectively. Investigation of the associations between the acquisitions of the blaCTX-M and qnr genes showed that acquisition of a blaCTX-M gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance.
• Subjects:
  Antibacterial Antibiotics Antimicrobial Bacteria CTX-M Enterobacteriaceae ESBL Intestinal Microbiota Kluyvera Metagenomic QnrB QnrS Quinolone Research Resistance Genes Shewanella Algae The Netherlands Traveling

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• Source:
  Emerg Infect Dis. 20(4):649-657.
• Document Type:
  Journal Article
• Volume:
  20
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5363a37d50438c2db82abf06d40231e3851185d2077943fb19c55064bee7f37a
• Download URL:
  https://stacks.cdc.gov/view/cdc/22228/cdc_22228_DS1.pdf
• File Type:
  [PDF - 1.23 MB ]