Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
von Wintersdorff, Christian J.H. ; Penders, John ; Stobberingh, Ellen E. ; Lashof, Astrid M.L. Oude ; Hoebe, Christian J.P.A. ; ... More +
von Wintersdorff, Christian J.H. ; Penders, John ; Stobberingh, Ellen E. ; Lashof, Astrid M.L. Oude ; Hoebe, Christian J.P.A. ; Savelkoul, Paul H.M. ; Wolffs, Petra F.G. ; Less -
Description:
We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both blaCTX-M and qnrS, respectively. Investigation of the associations between the acquisitions of the blaCTX-M and qnr genes showed that acquisition of a blaCTX-M gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance.
Subject:
[+]
Antibacterial
Antibiotics
Antimicrobial
Bacteria
CTX-M
Enterobacteriaceae
ESBL
Intestinal Microbiota
Kluyvera
Metagenomic
QnrB
QnrS
Quinolone
Research
Resistance Genes
Shewanella Algae
The Netherlands
Traveling

Source:
Emerg Infect Dis. 20(4):649-657. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:5363a37d50438c2db82abf06d40231e3851185d2077943fb19c55064bee7f37a
File Type:

Supporting Files

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