High Rates of Antimicrobial Drug Resistance Gene Acquisition after International Travel, the Netherlands

von Wintersdorff, Christian J.H.; Penders, John; Stobberingh, Ellen E.; Lashof, Astrid M.L. Oude; Hoebe, Christian J.P.A.; Savelkoul, Paul H.M.; Wolffs, Petra F.G.

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High Rates of Antimicrobial Drug Resistance Gene Acquisition after International Travel, the Netherlands

Published Date:

Apr 2014

Source:

Emerg Infect Dis. 20(4):649-657.

[PDF-1.23 MB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

von Wintersdorff, Christian J.H. ; Penders, John ; Stobberingh, Ellen E. ; Lashof, Astrid M.L. Oude ; Hoebe, Christian J.P.A. ; ... More ▼

Description:

We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both blaCTX-M and qnrS, respectively. Investigation of the associations between the acquisitions of the blaCTX-M and qnr genes showed that acquisition of a blaCTX-M gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance.

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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