Epidemic of Mumps among Vaccinated Persons, the Netherlands, 2009–2012

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sane, Jussi ; Gouma, Sigrid ; Koopmans, Marion ; de Melker, Hester ; Swaan, Corien ; van Binnendijk, Rob ; Hahné, Susan
• Description:
  To analyze the epidemiology of a nationwide mumps epidemic in the Netherlands, we reviewed 1,557 notified mumps cases in persons who had disease onset during September 1, 2009-August 31, 2012. Seasonality peaked in spring and autumn. Most case-patients were males (59%), 18-25 years of age (67.9%), and vaccinated twice with measles-mumps-rubella vaccine (67.7%). Nearly half (46.6%) of cases occurred in university students or in persons with student contacts. Receipt of 2 doses of vaccine reduced the risk for orchitis, the most frequently reported complication (vaccine effectiveness [VE] 74%, 95% CI 57%-85%); complications overall (VE 76%, 95% CI 61%-86%); and hospitalization (VE 82%, 95% CI 53%-93%). Over time, the age distribution of case-patients changed, and proportionally more cases were reported from nonuniversity cities (p<0.001). Changes in age and geographic distribution over time may reflect increased immunity among students resulting from intense exposure to circulating mumps virus.
• Subjects:
  Epidemic Herd Immunity Immunization MMR Mumps Outbreaks Research Surveillance The Netherlands Vaccination Vaccine Viruses

  More +
• Source:
  Emerg Infect Dis. 20(4):643-648.
• Document Type:
  Journal Article
• Volume:
  20
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a03509ef54ae4626afa973b81e8eb0220299c1cc340e6132e51ec56b62e1f11b
• Download URL:
  https://stacks.cdc.gov/view/cdc/22224/cdc_22224_DS1.pdf
• File Type:
  [PDF - 694.19 KB ]