Perfluoroalkyl Substances and Fish Consumption

Details

• Personal Author:
  Anderson HA ; Blackowicz M ; Christensen KY ; Liu Y ; Raymond M ; Thompson BA ; Turyk M
• Description:
  Background: Perfluoroalkyl substances (PFAS) are an emerging class of contaminants. Certain PFAS are regulated or voluntarily limited due to concern about environmental persistence and adverse health effects, including thyroid disease and dyslipidemia. The major source of PFAS exposure in the general population is thought to be consumption of seafood. Objectives: In this analysis we examine PFAS levels and their determinants, as well as associations between PFAS levels and self-reported fish and shellfish consumption, using a representative sample of the U.S. population. Methods: Data on PFAS levels and self-reported fish consumption over the past 30 days were collected from the 2007-2008, 2009-2010, 2011-2012, and 2013-2014 cycles of the National Health and Nutrition Examination Survey. Twelve different PFAS were measured in serum samples from participants. Ordinary least squares regression models were used to identify factors (demographic characteristics and fish consumption habits) associated with serum PFAS concentrations. Additional models were further adjusted for other potential exposures including military service and consumption of ready-to-eat and fast foods. Results: Seven PFAS were detected in at least 30% of participants and were examined in subsequent analyses (PFDA, PFOA, PFOS, PFHxS, MPAH, PFNA, PFUA). The PFAS with the highest concentrations were PFOS, followed by PFOA, PFHxS and PFNA (medians of 8.3, 2.7, 1.5 and 1.0 ng/mL). Fish consumption was generally low, with a median of 1.2 fish meals and 0.14 shellfish meals, reported over the past 30 days. After adjusting for demographic characteristics, total fish consumption was associated with reduced MPAH, and with elevated PFDE, PFNA and PFuDA. Shellfish consumption was associated with elevations of all PFAS examined except MPAH. Certain specific fish and shellfish types were also associated with specific PFAS. Adjustment for additional exposure variables resulted in little to no change in effect estimates for seafood variables. Conclusions: PFAS are emerging contaminants with widespread exposure, persistence, and potential for adverse health effects. In the general population, fish and shellfish consumption are associated with PFAS levels, which may indicate an avenue for education and outreach. [Description provided by NIOSH]
• Subjects:
  Diet Environmental Exposure Environmental Pollution Epidemiology Hunting Occupational Health Safety
• Keywords:
  Author Keywords: PFAS Chemicals Environmental Contamination Environmental Pollution Fish Fishing Health Effects NHANES Per- And Polyfluoroalkyl Substances PFAS PFOA PFOS Pollutants Shellfish

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  145-151
• Volume:
  154
• NIOSHTIC Number:
  nn:20063542
• Citation:
  Environ Res 2017 Apr; 154:145-151
• Contact Point Address:
  Krista Y. Christensen, Wisconsin Division of Public Health, Bureau of Environmental and Occupational Health, 1 West Wilson Street, Room 145, Madison, WI 53703, United States
• Email:
  Krista.Christensen@wisconsin.gov
• CAS Registry Number:
  Perfluorohexanesulfonic acid (CAS RN 355-46-4) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1) ; Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8908578abda3f2120b11797a1b0651fc530d82843f96bd0ba12fb92cbde1eafd24c2b388a75cede6869bd86449f69321ab3962e789169045a3fa3ed7379ec0bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/222131/cdc_222131_DS1.pdf
• File Type:
  [PDF - 655.64 KB ]