Persistent Organic Pollutants and Biomarkers of Diabetes Risk in a Cohort of Great Lakes Sport Caught Fish Consumers

Details

• Personal Author:
  Anderson HA ; Fantuzzi G ; Freels S ; Lambertino A ; Persky V ; Pini M ; Rhodes DH ; Turyk M
• Description:
  Background: Exposure to persistent organic pollutants (POPs) is associated with increased diabetes risk, although the mechanism of action is not well delineated. Methods: We investigated established diabetes biomarkers that could implicate potential mechanistic pathways, including C-reactive protein (CRP), a marker of systemic inflammation; gamma glutamyl transferase (GGT), a liver enzyme associated with oxidative stress; and adiponectin, an adipokine modulating glucose regulation and fatty acid oxidation. These biomarkers as well as hemoglobin A1c (HA1c), and POPs [polychlorinated biphenyls (PCBs), p,p-dichlorodiphenyldichloroethylene (DDE) and polybrominated diphenyl ethers (PBDEs)] were measured in a cohort of Great Lakes sport caught fish (GLSCF) consumers. We examined associations of POPs and fish consumption with HA1c and incident diabetes, and evaluated mediation and moderation by the diabetes biomarkers. Results: Odds of incident diabetes were elevated with exposure to DDE and PCBs. DDE and PCB 118 were positively, and fish meals were inversely, associated with HA1c. CRP was inversely associated with saltwater and total fish meals, particularly in persons with higher adiposity, but did not mediate the associations of fish meals with HA1c. There were few associations of POPs with adiponectin, CRP and GGT, with the exception of positive associations of PCB 118 with GGT, PBDEs with GGT in older persons, and PBDEs with adiponectin. Adiponectin, CRP and GGT did not mediate associations of DDE and PCBs with HA1c or incident diabetes. However, the association of DDE with HA1c was stronger in persons with higher CRP, GGT and BMI, and lower adiponectin, while the association of PCB 118 with HA1c was stronger in persons with higher GGT. Conclusions: These findings suggest that adiponectin, CRP and GGT did not mediate effects of POPs on diabetes or HA1c. However, POPs may have stronger effects on blood glucose in persons at higher risk for diabetes. [Description provided by NIOSH]
• Subjects:
  Blood Diet Environmental Exposure Environmental Pollution Epidemiology Hematologic Diseases Hunting Occupational Health Polychlorinated Biphenyls Safety
• Keywords:
  Adiponectin Author Keywords: Persistent Organic Pollutants Blood Sugar Disorders C-reactive Protein DDE Diabetes Environmental Contamination Environmental Pollution Fish Consumption Fishing Gamma Glutamyl Transferase Health Effects PCBs Pollutants

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Kansas ; OSHA Region 5 ; OSHA Region 7 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  335-344
• Volume:
  140
• NIOSHTIC Number:
  nn:20063525
• Citation:
  Environ Res 2015 Jul; 140:335-344
• Contact Point Address:
  Mary Turyk, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Room 887, (M/C 923), Chicago, IL 60612, United States
• Email:
  mturyk1@uic.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0de278a320da51b528149a2a02075b70543c28e599a626cec9424fe1144683d60bfd8a99e581895cd00ea8d4a84f0b255c69839492ec5d41da185f65868b19d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/222115/cdc_222115_DS1.pdf
• File Type:
  [PDF - 618.30 KB ]