Effects of Age and Dietary Antioxidants on Cerebral Electron Transport Chain Activity

Details

• Personal Author:
  Bondy SC ; Sharman EH
• Description:
  Aging is a pleiotropic process involving genetic and environmental factors. Recently it has been demonstrated that dietary constituents may affect senescence. In the present study, adult (3 month-old) mice were fed diets supplemented with ubiquinone (coenzyme Q10), a-lipoic acid, melatonin or a-tocopherol for a six-month period to determine if antioxidants may reverse or inhibit the progression of certain age-associated changes in cerebral mitochondrial electron transport chain (ETS) enzyme activities. The control consisted of a group of mice maintained on a basal diet for the same period. The activity of cytochrome c oxidase (Complex IV) increased with age but melatonin supplementation restored the activity to levels of 3 month-old animals. The activity of succinate dehydrogenase (Complex II) showed no age-related changes. However, this enzyme complex was elevated, in animals supplemented with coenzyme Q10, a-lipoic acid and a-tocopherol, above corresponding values obtained with basal diet. NADH-ubiquinone oxidoreductase (Complex I) and ubiquinol:ferricytochrome-c oxidoreductase (Complex III) activities remained unchanged. [Description provided by NIOSH]
• Subjects:
  Aging Animals Antioxidants Diet Enzymes Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Diet Brain Brain Electrical Activity Coenzyme-Q10 Dietary Effects Enzyme Activity Lipoic Acid Melatonin Tocopherol Ubiquinone

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• ISSN:
  0197-4580
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  4
• NIOSHTIC Number:
  nn:20058218
• Citation:
  Neurobiol Aging 2001 Jul-Aug; 22(4):629-634
• Contact Point Address:
  Edward H. Sharman, Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA, 92697-1825, USA
• CAS Registry Number:
  Melatonin (CAS RN 73-31-4)
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Neurobiology of Aging
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b4b091813cf2ab8751c2bb3bf0d4f16dc80186a04dc131f096ed5d84fbe2a4795121327e948662cacf8f26ec2d5e9801426ba39cf50a84f791f9dfa3b1b7d85d
• Download URL:
  https://stacks.cdc.gov/view/cdc/221351/cdc_221351_DS1.pdf
• File Type:
  [PDF - 158.42 KB ]