Age-Related Changes in Murine CNS mRNA Gene Expression Are Modulated by Dietary Melatonin

Details

• Personal Author:
  Bondy SC ; Ge Y-W ; Lahiri DK ; Sharman EH ; Sharman KG
• Description:
  Brain cellular functions decline with normal aging, accompanied by a changing profile of gene expression. Gene array analysis was used to quantitatively estimate messenger RNA (mRNA) expression levels in the cerebral cortex of both young (4-month) and old (27-month) B6C3F1 male mice. A stringent degree of significance was obtained by using multiple gene chips. Out of 12,423 mRNA levels, only 25 changed significantly with age. Nine of these genes coded for inflammatory proteins, all of which were elevated in aged, relative to younger mice. Melatonin (200 p.p.m.) included in the diet of aged animals for 8 wk elevated serum and cortical melatonin and reversed 13 of the 25 genes altered with age. In no case did melatonin potentiate age-related changes in gene expression. The restoration of a more youthful gene profile to brains of aged animals by melatonin, to a large extent, involves reversal of age-induced elevation of basal inflammatory parameters. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Animals Diet Occupational Health Safety
• Keywords:
  Age Factors Animal Studies Author Keywords: Aging Brain Brain Function Cellular Function Dietary Effects Gene Expression Longevity Melatonin Messenger RNA Mouse

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• ISSN:
  0742-3098
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Indiana ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  165-170
• Volume:
  36
• Issue:
  3
• NIOSHTIC Number:
  nn:20058221
• Citation:
  J Pineal Res 2004 Apr; 36(3):165-170
• Contact Point Address:
  Edward H. Sharman PhD, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1825, USA
• Email:
  esharman@uci.edu
• CAS Registry Number:
  Melatonin (CAS RN 73-31-4)
• Federal Fiscal Year:
  2004
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Journal of Pineal Research
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:998cccbd3266b1e4430f2111fd939980867973acd0ffe315aec84e80412196443e0fbde829dd80243b93ff90737abd033bac4aad81bc4a960070402d18f4f4e8
• Download URL:
  https://stacks.cdc.gov/view/cdc/221354/cdc_221354_DS1.pdf
• File Type:
  [PDF - 122.06 KB ]