Oxidative and Inflammatory Properties of Aluminum: Possible Relevance in Alzheimer’s Disease

Details

• Personal Author:
  Bondy SC ; Campbell A
• Description:
  Both inflammation and the production of reactive oxygen species may be beneficial short-term response to extracellular stressors, and kill pathogens that have accessed nervous tissue. These factors, however, when active over an extended period following an ineffectual response to a persistent stimulus, can become harmful. Colloidal Al could constitute such irresolvable foci that cannot be cleared by activated microglia. This can lead to chronic inflammatory responses that eventually overwhelm neurons and impair their function. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Immune System Occupational Health Safety
• Keywords:
  Aluminum Cellular Reactions Immune Reaction Neurological Diseases Neurological Reactions Neurological System Reactive Oxygen Species ROS
• ISBN:
  9780444508119
• Publisher:
  Elsevier Science
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  311-321
• NIOSHTIC Number:
  nn:20058044
• Citation:
  Aluminium and Alzheimer's disease: the science that describes the link. Exley C ed. Amsterdam: Elsevier Science, 2001 Jul; :311-321
• Contact Point Address:
  Stephen C Bondy, Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California Irvine, Irvine, California 92697-1820, USA
• Email:
  scbondy@uci.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Editor(s):
  Exley C
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  False
• Start Date:
  19990701
• Source Full Name:
  Aluminium and Alzheimer's disease: the science that describes the link
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73857f83245743e682069ce9d7630dfdd422bd7c06422f62860dda560ad1333670bd938faa232714fd7036d1e1b9c519226a135e3e3a1d288de4c0ab8804eb3c
• Download URL:
  https://stacks.cdc.gov/view/cdc/221234/cdc_221234_DS1.pdf
• File Type:
  [PDF - 1.93 MB ]