Aluminum Increases Levels of Beta-Amyloid and Ubiquitin in Neuroblastoma but Not in Glioma Cells

Details

• Personal Author:
  Bondy SC ; Campbell A ; Kumar A ; La Rosa FG ; Prasad KN
• Description:
  Several epidemiological studies suggest the involvement of aluminum (AI) in the pathogenesis of Alzheimer's disease (AD). There is an increase in the levels of Abeta and ubiquitin in the pathological lesions of AD. Therefore, we have investigated whether aluminum (AI) treatment alters the levels of Abeta and ubiquitin in murine neuroblastoma (NBP2) and rat glioma (C-6) cell cultures. At a low concentration (10 uM), aluminum sulfate stimulated the level of immunoreactive Abeta and ubiquitin in NBP2 cells without changing the levels of the amyloid precursor protein (APP). However, at higher concentrations (100 and 500 uM), aluminum failed to elicit any significant effect on beta-amylold, whereas ubiquitin levels continued to increase. No changes in the Abeta and ubiquitin content were found in the C-6 glioma cells following treatment with AI at any of the concentrations tested. Exposure of cells to aluminum salts did not alter the rate of proliferation in either of the two cell lines. These data suggest that one of the mechanisms by which AI may play a role in AD is by promoting the formation of Abeta and ubiquitin in neurons. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Animals Immune System Nervous System Occupational Health Safety
• Keywords:
  Aluminum Animal Studies Brain Disorders Immune Reaction Neurological System Neuropathology Pathogenesis
• ISSN:
  0037-9727
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  397-402
• Volume:
  223
• Issue:
  4
• NIOSHTIC Number:
  nn:20058048
• Citation:
  Proc Soc Exp Biol Med 2000 Apr; 223(4):397-402
• Contact Point Address:
  S. C Bondy, Department of Community & Environmental Medicine, University of California, Irvine, CA 92697-1820
• Email:
  scbondy@uci.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Federal Fiscal Year:
  2000
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Proceedings of the Society for Experimental Biology and Medicine
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0c76640292a12da70cf167d02c993b17cc5fa8bfb608c826d409c57d053e6abee24388b93d7e352e9d0650d3b5887a1d17efd7689c067f7b48571034d66af41d
• Download URL:
  https://stacks.cdc.gov/view/cdc/221236/cdc_221236_DS1.pdf
• File Type:
  [PDF - 531.62 KB ]