Short–and Medium-Term Associations of Particle Number Concentration with Cardiovascular Markers in a Puerto Rican Cohort

Details

• Personal Author:
  Brugge D ; Chang HH ; Fuller CH ; O'Neill MS ; Sarnat JA ; Tucker KL
• Description:
  Air pollution has been linked to adverse cardiovascular outcomes; however, susceptibility may vary by population. Puerto Rican adults living in the US may be a susceptible group due to a high rate of adverse cardiovascular events. We evaluated the effect of changes in ambient particle number concentration (PNC, a measure of ultrafine particles) and effects on biomarkers of cardiovascular risk in the Boston Puerto Rican Health Study (BPRHS), a longitudinal cohort (n = 1499). Ambient PNC was measured at a fixed site between 2004 and 2013 and daily mean concentrations were used to construct PNC metrics, including lags of 0, 1 and 2 days and moving averages (MAs) of 3, 7 and 28 days. We examined the association of each metric with C-reactive protein (CRP) and blood pressure. Each model included subject-specific random intercepts to account for multiple measurements. An interquartile range (IQR) increase in PNC was associated with CRP for all metrics, notably a 3-day increase in PNC was associated with a 7.1% (95% CI: 2.0%, 12.2%) increase in CRP. Significant associations with CRP were seen in women, but not men; with current and former (but not non-) smokers; participants younger (but not older) than 65 y; those without diabetes (but not with), and those with (but not without), hypertension. Our study extends knowledge about the health effects of air pollution to a vulnerable population that has been understudied. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Occupational Health Safety
• Keywords:
  Air Pollution Author Keywords: Particles Blood Pressure Cardiovascular Cardiovascular Disease Health Effects Hispanic Puerto Rican Ultrafine Particles
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  166
• NIOSHTIC Number:
  nn:20055245
• Citation:
  Environ Res 2018 Oct; 166:595-601
• Contact Point Address:
  Christina H. Fuller, Georgia State University School of Public Health, P.O. Box 3995, Atlanta, GA 30302-3995, United States
• Email:
  cfuller@gsu.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb2043d90702dc33c1a3652686b0b9fe0d500022a3dc39e1c935ab054d43dc48ae1d4eb43bbf5d004d8ef39db51a3796ad6333f6f79aa2783e8a8b74bf7043eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/217591/cdc_217591_DS1.pdf
• File Type:
  [PDF - 484.27 KB ]