Cross-Sectional Analysis of the Association Between Personal Exposure to Household Air Pollution and Blood Pressure in Adult Women: Evidence from the Multi-Country Household Air Pollution Intervention Network (HAPIN) Trial

Details

• Personal Author:
  Checkley W ; Clark M ; Davila-Roman V ; de las Fuentes L ; Diaz A ; HAPIN Investigators ; Hossen S ; Jabbarzadeh S ; McCracken JP ; Nicolaou L ; Peel JL ; Pillarisetti A ; Quinn AK ; Rosa G ; Simkovich S ; Steenland, Kyle ; Thangavel G ; Underhill L ; Waller LA
• Description:
  Elevated blood pressure (BP) is a leading risk factor for the global burden of disease. Household air pollution (HAP), resulting from the burning of biomass fuels, may be an important cause of elevated BP in resource-poor communities. We examined the exposure-response relationship of personal exposures to HAP -fine particulate matter (PM2.5), carbon monoxide (CO), and black carbon (BC) - with BP measures in women aged 40-79 years across four resource-poor settings in Guatemala, Peru, India and Rwanda. BP was obtained within a day of 24-h personal exposure measurements at baseline, when participants were using biomass for cooking. We used generalized additive models to characterize the shape of the association between BP and HAP, accounting for the interaction of personal exposures and age and adjusting for a priori identified confounders. A total of 418 women (mean age 52.2 +/- 7.9 years) were included in this analysis. The interquartile range of exposures to PM2.5 was 42.9-139.5 µg/m3, BC was 6.4-16.1 µg/m3, and CO was 0.5-2.9 ppm. Both SBP and PP were positively associated with PM2.5 exposure in older aged women, achieving statistical significance around 60 years of age. The exact threshold varied by BP measure and PM2.5 exposures being compared. For example, SBP of women aged 65 years was on average 10.8 mm Hg (95% CI 1.0-20.6) higher at 232 µg/m3 of PM2.5 exposure (90th percentile) when compared to that of women of the same age with personal exposures of 10 µg/m3. PP in women aged 65 years was higher for exposures ≥90 µg/m3, with mean differences of 6.1 mm Hg (95% CI 1.8-10.5) and 9.2 mm Hg (95% CI 3.3-15.1) at 139 (75th percentile) and 232 µg/m3 (90th percentile) respectively, when compared to that of women of the same age with PM2.5 exposures of 10 µg/m3. Our findings suggest that reducing HAP exposures may help to reduce BP, particularly among older women. [Description provided by NIOSH]
• Subjects:
  Air Pollution, Indoor Cardiovascular Diseases Cardiovascular System Environmental Exposure Fuel Oils Occupational Health Particulate Matter Safety Women
• Keywords:
  Author Keywords: Blood Pressure Blood Pressure Cardiovascular Disease Cardiovascular Diseases Cooking Equipment Environmental Exposure Fuels Household Air Pollution Indoor Air Pollution Low- And Middle-income Countries Particulates

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; District of Columbia ; Georgia ; Maryland ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  214
• NIOSHTIC Number:
  nn:20067174
• Citation:
  Environ Res 2022 Nov; 214(Pt 4):114121
• Contact Point Address:
  William Checkley, Johns Hopkins University, Division of Pulmonary and Critical Care, School of Medicine, 1830 E. Monument St. Room 555, Baltimore, MD 21287
• Email:
  wcheckl1@jhmi.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Part Number:
  4
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:52d24674ef11f54bc34b93b2f90eb8a7d82663a664af92896b6a5829eb4dab3a428eb8a2996e9c8866d3bd01db4dec2ade9599fb0145d8a93263092b31c4c86b
• Download URL:
  https://stacks.cdc.gov/view/cdc/231314/cdc_231314_DS1.pdf
• File Type:
  [PDF - 7.78 MB ]