Air Pollution and Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Adar SD ; Allen RW ; Auchincloss AH ; Curl CL ; Diez Roux AV ; Gill EA ; Kaufman JD ; O'Neill MS ; Park SK ; Van Hee VC
• Description:
  Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovascular mortality, coronary heart disease events, and stroke. The biologic mechanisms underlying this long-term exposure relationship are not entirely clear but are hypothesized to include systemic inflammation, autonomic nervous system imbalance, changes in vascular compliance, altered cardiac structure, and development of atherosclerosis. The Multi-Ethnic Study of Atherosclerosis provides an especially well-characterized population in which to investigate the relationship between air pollution and CVD and to explore these biologic pathways. This article reviews findings reported to date within this cohort and summarizes the aims and anticipated contributions of a major ancillary study, the Multi-Ethnic Study of Atherosclerosis and Air Pollution. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Author Keywords: Air Pollution Cardiovascular Disease Health Effects Particulates Progression Subclinical Atherosclerosis
• ISSN:
  0033-0620
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  353-360
• Volume:
  53
• Issue:
  5
• NIOSHTIC Number:
  nn:20054956
• Citation:
  Prog Cardiovasc Dis 2011 Mar; 53(5):353-360
• Contact Point Address:
  Edward A. Gill, MD, Professor, Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359748, Seattle, WA 98104
• Email:
  eagill@u.washington.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Progress in Cardiovascular Diseases
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e47b278d2ece6344326090836f8f7e64c3b6aa5f967b276171161f457d1c7446bd8c61008d213fdea731b561af45ffb268bf3f45d1715dd51f9bd1405c352621
• Download URL:
  https://stacks.cdc.gov/view/cdc/217362/cdc_217362_DS1.pdf
• File Type:
  [PDF - 429.28 KB ]