APOM and High-Density Lipoprotein Cholesterol Are Associated with Lung Function and per Cent Emphysema

Details

• Personal Author:
  Ahmed FS ; Barr RG ; Burkart KM ; Burke GL ; Enright, Paul L. ; Hansel NN ; Haynes D ; Heckbert SR ; Hoffman EA ; Kaufman JD ; Kurai J ; Loehr L ; London SJ ; Manichaikul A ; Meng Y ; O'Connor GT ; Oelsner E ; Petrini M ; Pottinger TD ; Powell CA ; Redline S ; Rich SS ; Rotter JI ; Smith LJ ; Soler Artigas M ; Tobin MD ; Tsai MY ; Watson K ; White W ; Wilk JB ; Young TR
• Description:
  Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3×10-6) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38×10-7). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV1/FVC ratio and greater per cent emphysema. These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Epidemiology Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Air Pollution Chronic Obstructive Pulmonary Disease Cohort Studies COPD Health Effects Lung Function Particulates
• ISSN:
  0903-1936
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Illinois ; Iowa ; Massachusetts ; Minnesota ; Mississippi ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9 ; Virginia ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  43
• Issue:
  4
• NIOSHTIC Number:
  nn:20055105
• Citation:
  Eur Respir J 2014 Apr; 43(4):1003-1017
• Contact Point Address:
  R.G. Barr, Columbia University Medical Center, 630 West 168th Street, PH 9 East - Room 105, New York, NY 10032, USA
• Email:
  rgb9@columbia.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Respiratory Journal
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:267dceb314384663da9374de01352897b6295fd72ebe85ca512601c4c934ec3d2e90bd1eb85931482c778b51cdb724c44d9fc3985fd43781ec5010acaaf96b8f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217474/cdc_217474_DS1.pdf
• File Type:
  [PDF - 744.13 KB ]