Longitudinal Lung Function Effects of Particulate Matter in Children with Cystic Fibrosis

Details

• Personal Author:
  Caldwell E ; Goss CH ; Hinckley Stukovsky KD ; Kaufman JD ; Sheppard L ; Vedal S
• Description:
  Background/Aims: Chronic exposure to ambient-source particulate matter (PM) is associated with decreased lung function growth in healthy children. Children with cystic fibrosis (CF) have decreased lung function and decreased lung function growth, compared to normal children, and may be highly susceptible to the adverse chronic effects of air pollution exposure. Methods: Data were obtained from the Cystic Fibrosis Foundation Patient Registry. Included were Caucasian children 6-18 years of age with at least 1 spirometry measure from 1994 to 2006. Ambient levels of PM less than 2.5 um in diameter (PM2.5) and less than 10 um in diameter (PM10) were obtained from the US Environmental Protection Agency and estimated using year 2000 annual average concentration at the closest population-based monitor within 30 miles of the patient's home zip code centroid. FVC and FEV1 were regressed on age-adjusted height, age, year of birth (cohort effect), and 2-way interactions, using linear spline models including cross-sectional effects at age 6, stratified by gender. Results: A total of 5204 (54.0%) patients lived within 30 miles of a PM2.5 monitor and 2892 (30.2%) lived within 30 miles of a PM10 monitor. Annual average PM2.5 ranged from 5.5 to 28.2 ug/m3 for males and 3.8-28.2 ug/m3 for females. PM10 annual average ranged from 12.2-52.0 ug/m3 for males and 12.2-83.2 ug/m3 for females. A 10 ug/m3 increase in PM2.5 exposure was associated with a 10.10mL/yr (95% CI: -19.93, -0.32) decrement in FEV1 for males and 10.10 mL/yr (95% CI: -18.29, -1.91) in females. 10-year trend due to cohort effect was associated with a 5.91mL/yr (95% CI: -2.20, 14.02) and a 7.02 mL/yr (95% CI: 0.13, 13.90) increase in FEV1 in males and females, respectively. A 10 ug/m3 increase in PM10 was not found to be significantly associated with reduced lung function growth. Conclusion: Chronic exposure to ambient PM2.5 is associated with decreased lung function growth in children with cystic fibrosis. This effect is greater than the increase in FEV1 and FVC associated with longitudinal treatment trends. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Air Pollution Children Cohort Studies Environmental Health Health Effects Lung Fibrosis Lung Function Particulates
• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20054896
• Citation:
  Epidemiology 2011 Jan; 22(1)(Jan Suppl 2011):S200
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• Supplement:
  Jan Suppl 2011
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61d2328ffe61c67f39871196d3d00323707d74bcb975ac0140ddbbbe32c6e6316f6ea9bdad63f89ac9b50fd38ac5fec754d6036bc22a5aafdc4166d15464149c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217309/cdc_217309_DS1.pdf
• File Type:
  [PDF - 49.16 KB ]