Longitudinal Lung Function Effects of Fine Particulate Matter in Children with Cystic Fibrosis

Details

• Personal Author:
  Caldwell ES ; Goss CH ; Hinckley Stukovsky KD ; Kaufman JD ; Sheppard L ; Vedal S
• Description:
  Background: Chronic exposure to ambient-source fine particulate matter (PM2.5) is associated with decreased lung function in healthy children. Because children with cystic fibrosis (CF) have decreased lung function, they may be highly susceptible to the adverse chronic effects of air pollution exposure. Methods: Data were obtained from the Cystic Fibrosis Foundation Patient Registry. Included were Caucasian children 6-18 years of age with at least one spirometry measure from 1994-2006. Ambient levels of PM2.5 were obtained from the US EPA and estimated using the year 2000 annual average concentration at the population-based monitor closest to the patient's home zip code centroid, within 30 miles of the residence. FVC and FEV1 were regressed separately for males and females on age-adjusted height, age, year of birth (cohort effect), and two-way interactions using linear spline models including cross-sectional effects at age 6. Results: 5,204 (54.0%) patients lived within 30 miles of a population-based PM2.5 monitor. Annual average PM2.5 ranged from 5.5-28.2ug/m3 for males and 3.8-28.2ug/m3 for females. A 10 ug/m3 increase in PM exposure was significantly associated with a 2.5 10ml/year decrement in lung function for both males and females. 10-year trend due to cohort effect was associated with a 6ml/year and a 7ml/year increase in FEV1 in males and females, respectively. Conclusions: Chronic exposure to ambient PM2.5 is associated with decreased lung function, over time, in children with cystic fibrosis. This effect is greater than the increase in FEV1 and FVC associated with birth cohort over time. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Air Pollution Children Cohort Studies Environmental Health Health Effects Lung Fibrosis Lung Function Particulates
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  181
• NIOSHTIC Number:
  nn:20054877
• Citation:
  Am J Respir Crit Care Med 2010 May; 181(Meeting Abstracts):A4630
• Email:
  hincklek@uw.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Meeting Abstracts
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5072af789a66a4132e973ae6f775c889073d1689294e9999fee59ef8124f54a80f22ecca149fc13ef7c236e8b7f83fe9c7852a70f4e1bb8415419786d69c1c27
• Download URL:
  https://stacks.cdc.gov/view/cdc/217291/cdc_217291_DS1.pdf
• File Type:
  [PDF - 19.44 KB ]