25-Hydroxyvitamin D and Parathyroid Hormone Are Not Associated with Carotid Intima-Media Thickness or Plaque in the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Blondon M ; de Boer IH ; Gepner AD ; Hoofnagle AN ; Ix JH ; Kaufman JD ; Kestenbaum B ; Korcarz C ; Michos ED ; Sachs M ; Siscovick DS ; Stein JH
• Description:
  Objective: Observational evidence supports independent associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) with cardiovascular risk. A plausible hypothesis for these associations is accelerated development of atherosclerosis. Approach and Results: We evaluated cross-sectional and longitudinal associations of 25-OHD and PTH with carotid intima-media thickness (IMT) and carotid plaques among 3251 participants free of cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. 25-OHD and PTH were measured at baseline by mass spectrometry and immunoassay, respectively. All subjects underwent a carotid ultrasound examination at baseline and 9.4 years later (median, range 8-11.1 years). Multivariable linear and logistic regressions were used to test associations of 25-OHD and PTH with the extent and progression of IMT and the prevalence and incidence of carotid plaque. Mean (SD) 25-OHD and PTH were 25.8 ng/mL (10.6) and 44.2 pg/mL (20.2), respectively. No independent associations were found between 25-OHD or PTH and IMT at baseline (increment of 1.9 um [95% confidence interval, -5.1 to 8.9] per 10 ng/mL lower 25-OHD; increment of 0.8 um [95% confidence interval, -3.2 to 4.8] per 10 pg/mL higher PTH) or progression of IMT (increment of 2.6 um [95% confidence interval, -2.5 to 7.8] per 10 ng/mL lower 25-OHD, increment of 1.6 um [95% confidence interval, -1.9 to 5.2] per 10 pg/mL higher PTH). No associations were found with the baseline prevalence of carotid plaque or the incidence of new plaques during the study period. We did not observe any interaction by race or ethnicity (White, Chinese, Black, and Hispanic). Conclusions: The consistent lack of association of vitamin D and PTH with carotid IMT and plaque suggests that these hormones may influence cardiovascular risk through pathways not reflected by carotid atherosclerosis. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Particulate Matter Risk Assessment Risk Factors Safety
• Keywords:
  Air Pollution Atherosclerotic Plaque Author Keywords: Atherosclerosis Cardiovascular Disease Carotid Intima-media Thickness Cohort Studies Corotid Artery Disease Cross Sectional Studies Health Effects Mineral Metabolism Parathyroid Hormone Particulates Risk Factors Vitamin D Vitamins

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• ISSN:
  1079-5642
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Maryland ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  11
• NIOSHTIC Number:
  nn:20055101
• Citation:
  Arterioscler Thromb Vasc Biol 2013 Nov; 33(11):2639-2645
• Contact Point Address:
  Marc Blondon, MD, MS, University of Washington, Cardiovascular Health Research Unit, Metropolitan Park E Tower, 1730 Minor Ave, Suite 1360, Seattle, WA 98101
• Email:
  blondm@uw.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Arteriosclerosis, Thrombosis, and Vascular Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00bb592d4d0d28419f44fb1bc6bfe6a52c1b51d0f8b67407c3814dc9488570cc11f4c2c86a0760f7264fdb218e9966c80131d7313aa847506e250fa98147a1b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/217471/cdc_217471_DS1.pdf
• File Type:
  [PDF - 438.66 KB ]