25-Hydroxyvitamin D and Parathyroid Hormone Levels Do Not Predict Changes in Carotid Arterial Stiffness: The Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Blondon M ; Colangelo LA ; de Boer IH ; Gepner AD ; Kaufman JD ; Kestenbaum B ; Korcarz CE ; Liu K ; Siscovick DS ; Stein JH
• Description:
  Objective: To evaluate the impact of vitamin D and parathyroid hormone (PTH) on longitudinal changes in arterial stiffness. Approach and Results: Distensibility coefficient and Young's elastic modulus of the right common carotid artery were evaluated at baseline and after a mean (SD) of 9.4 (0.5) years in 2580 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Cross-sectional and longitudinal associations were evaluated using multivariable linear regression and analysis of covariance. At baseline, participants were 60.1 (9.4) years old (54% female; 26% black, 20% Hispanic, 14% Chinese). Mean annualized 25(OH)D was <20 ng/dL in 816 participants, and PTH was >65 pg/dL in 285 participants. In cross-sectional analyses, low 25(OH)D (<20 ng/mL) was not associated with stiffer arteries after adjustment for cardiovascular disease risk factors (P>0.4). PTH >65 pg/mL was associated with stiffer arteries after adjustment for cardiovascular disease risk factors, other than systolic blood pressure (distensibility coefficient: B=-2.4×10-4 mm Hg-1, P=0.003; Young's elastic modulus: B=166 mm Hg, P=0.01); however, after adjustment for systolic blood pressure, these associations no longer were statistically significant. Longitudinal arterial stiffening was associated with older age (P<0.0001), higher systolic blood pressure (P<0.008), and use of antihypertensive medications (P<0.006), but not with 25(OH)D or PTH (both P>0.1). Conclusions: Carotid arterial stiffness is not associated with low 25(OH)D concentrations. Cross-sectional associations between arterial stiffness and high PTH were attenuated by systolic blood pressure. After nearly a decade of follow-up, neither baseline PTH nor 25(OH)D concentrations were associated with progression of carotid arterial stiffness. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Particulate Matter Risk Assessment Risk Factors Safety
• Keywords:
  Air Pollution Author Keywords: Cardiovascular Diseases Blood Pressure Cardiovascular Disease Carotid Arteries Cohort Studies Cross Sectional Studies Health Effects Parathyroid Hormone Particulates Risk Factors Vascular Stiffness Vitamin D Vitamins

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• ISSN:
  1079-5642
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 10 ; OSHA Region 5 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  34
• Issue:
  5
• NIOSHTIC Number:
  nn:20055125
• Citation:
  Arterioscler Thromb Vasc Biol 2014 May; 34(5):1102-1109
• Contact Point Address:
  James H. Stein, MD, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, H4/520 CSC (MC 3248), Madison, WI 53792
• Email:
  jhs@medicine.wisc.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Arteriosclerosis, Thrombosis, and Vascular Biology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:843a27102de1a2b9e355096605848c76033bc670e5280389162a4a67a367e6977d8e49ad0ae8ac2bb447af342fab01b33000bb83aa33920cdea70d20bd853321
• Download URL:
  https://stacks.cdc.gov/view/cdc/217492/cdc_217492_DS1.pdf
• File Type:
  [PDF - 437.39 KB ]