Individual-Level Concentrations of Fine Particulate Matter Chemical Components and Subclinical Atherosclerosis: A Cross-Sectional Analysis Based on 2 Advanced Exposure Prediction Models in the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Adar SD ; Bergen S ; Diez Roux AV ; Kaufman JD ; Kim S-Y ; Larson TV ; Polak JF ; Sheppard L ; Szpiro AA ; Vedal S
• Description:
  Long-term exposure to outdoor particulate matter with an aerodynamic diameter less than or equal to 2.5 µm (PM2.5) has been associated with cardiovascular morbidity and mortality. The chemical composition of PM2.5 that may be most responsible for producing these associations has not been identified. We assessed cross-sectional associations between long-term concentrations of PM2.5 and 4 of its chemical components (sulfur, silicon, elemental carbon, and organic carbon (OC)) and subclinical atherosclerosis, measured as carotid intima-media thickness (CIMT) and coronary artery calcium, between 2000 and 2002 among 5,488 Multi-Ethnic Study of Atherosclerosis participants residing in 6 US metropolitan areas. Long-term concentrations of PM2.5 components at participants' homes were predicted using both city-specific spatiotemporal models and a national spatial model. The estimated differences in CIMT associated with interquartile-range increases in sulfur, silicon, and OC predictions from the spatiotemporal model were 0.022 mm (95% confidence interval (CI): 0.014, 0.031), 0.006 mm (95% CI: 0.000, 0.012), and 0.026 mm (95% CI: 0.019, 0.034), respectively. Findings were generally similar using the national spatial model predictions but were often sensitive to adjustment for city. We did not find strong evidence of associations with coronary artery calcium. Long-term concentrations of sulfur and OC, and possibly silicon, were associated with CIMT using 2 distinct exposure prediction modeling approaches. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Author Keywords: Atherosclerosis Cardiovascular Disease Cardiovascular Diseases Carotid Intima-media Thickness Cohort Studies Exposure Assessment Particulate Matter Particulates
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  180
• Issue:
  7
• NIOSHTIC Number:
  nn:20054801
• Citation:
  Am J Epidemiol 2014 Oct; 180(7):718-728
• Contact Point Address:
  Dr. Sun-Young Kim, Room 717, Building 220, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea
• Email:
  puha0@uw.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82d160ab98ace0fc6ab1abb38bffbc6d70751282875e062295ef25e64cff54f80cd134af2783682454c5347418b7c4cf3d683594d82036ace182cd95107bab7e
• Download URL:
  https://stacks.cdc.gov/view/cdc/217231/cdc_217231_DS1.pdf
• File Type:
  [PDF - 324.41 KB ]