Posttraumatic Stress Disorder and Total Amyloid Burde and Amyloid-B 42/40 Ratios in Plasma: Reaults from a Pilot Study of World Trade Center Responders

Details

• Personal Author:
  Bromet EJ ; Clouston SAP ; Deri Y ; Diminich E ; Gandy S ; Kew R ; Kotov R ; Luft BJ ; Sano M ; Stewart C ; Yang X
• Description:
  Introduction: Chronic posttraumatic stress disorder (PTSD) is associated with poor memory and increased burden of various degenerative cerebral neuropathologies. The goal of this pilot study was to determine whether PTSD was associated with changes in plasma-based neuropathological biomarkers of neurodegeneration among World Trade Center (WTC) responders. Methods: Thirty-four WTC responders had blood drawn and flash-frozen within 15 minutes of retrieval. PTSD symptoms were assessed at that time. Age, sex, and WTC exposure duration were obtained from medical records. Plasma was assayed in duplicate using an ultra-sensitive single-molecule enzyme-linked immunosorbent assay to examine the distribution of amyloid-b (Ab) 42/40 ratios, total Ab, total tau, and neurofilament light (NfL). The comparison group was drawn from a bank of healthy controls collected and assayed at the same facility. Results: The average age of WTC responders at blood draw was 53 years. Half were PTSD positive (PTSD1) as indicated by symptom severity. WTC responders had lower Ab42/Ab40 ratios but higher total tau and NfL levels in the plasma than healthy controls. PTSD1 status was associated with lower plasma Ab load and higher Ab42/Ab40 ratios. Discussion: Findings suggest that PTSD may be associated with alterations in plasma markers related to Ab, tau, and NfL, highlighting the potential association between PTSD status and neurodegenerative neuropathology in WTC responders. [Description provided by NIOSH]
• Subjects:
  Aging Biomarkers Blood Emergency Responders Environmental Exposure Hematologic Tests Men Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Women

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• Keywords:
  Age Groups Amyloid Burden Author Keywords: World Trade Center Disaster Blood Plasma Blood Samples Cognitive Function Cognitive Impairment Emergency Responders Exposure Levels First Responders Humans Neurofilament-light Neurological Disorders Neuropathology Plasma Markers Of Neuropathology; Post-traumatic Stress Disorder Posttraumatic Stress PTSD Rescue Workers Risk Factors Tau World Trade Center WTC

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• ISSN:
  2352-8729
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  216-220
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20055045
• Citation:
  Alzheimers Dement Diagn Assess Dis Monit 2019 Dec; 11(1):216-220
• Contact Point Address:
  Sean A. P. Clouston, Department of Family, Population, and Preventive Medicine, Program in Public Health, Stony Brook University, Stony Brook, NY
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York City Health/Mental Hygiene
• Peer Reviewed:
  True
• Start Date:
  20090430
• Source Full Name:
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f6cc23372f525069e28f33b919eb6a9bf88c9549b6b4167529cbbf391870555eb0f98f1d370cdc5ff44d26e3989e1522de2c87cf791085ef90bedda2a909fdec
• Download URL:
  https://stacks.cdc.gov/view/cdc/217434/cdc_217434_DS1.pdf
• File Type:
  [PDF - 228.54 KB ]