Posttraumatic Stress Disorder and Total Amyloid Burden and Amyloid-Β 42/40 Ratios in Plasma: Results from a Pilot Study of World Trade Center Responders

Details

• Personal Author:
  Bromet EJ ; Clouston SAP ; Deri Y ; Diminich E ; Gandy S ; Kew R ; Kotov R ; Luft BJ ; Sano M ; Stewart C ; Yang X
• Description:
  Introduction: Chronic posttraumatic stress disorder (PTSD) is associated with poor memory and increased burden of various degenerative cerebral neuropathologies. The goal of this pilot study was to determine whether PTSD was associated with changes in plasma-based neuropathological biomarkers of neurodegeneration among World Trade Center (WTC) responders. Methods: Thirty-four WTC responders had blood drawn and flash-frozen within 15 minutes of retrieval. PTSD symptoms were assessed at that time. Age, sex, and WTC exposure duration were obtained from medical records. Plasma was assayed in duplicate using an ultra-sensitive single-molecule enzyme-linked immunosorbent assay to examine the distribution of amyloid-β (Aβ) 42/40 ratios, total Aβ, total tau, and neurofilament light (NfL). The comparison group was drawn from a bank of healthy controls collected and assayed at the same facility. Results: The average age of WTC responders at blood draw was 53 years. Half were PTSD positive (PTSD+) as indicated by symptom severity. WTC responders had lower Aβ42/Aβ40 ratios but higher total tau and NfL levels in the plasma than healthy controls. PTSD+ status was associated with lower plasma Aβ load and higher Aβ42/Aβ40 ratios. Discussion: Findings suggest that PTSD may be associated with alterations in plasma markers related to Aβ, tau, and NfL, highlighting the potential association between PTSD status and neurodegenerative neuropathology in WTC responders. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: Amyloid Burden Cognitive Function Cognitive Impairment Cohort Studies Mental Health Neurofilament-light Neuropathology Plasma Markers Of Neuropathology Post-traumatic Stress Disorder Posttraumatic Stress PTSD Tau World Trade Center World Trade Center Disaster WTC

  More +
• ISSN:
  2352-8729
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  216-220
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20068631
• Citation:
  Alzheimers Dement Diagn Assess Dis Monit 2019 Dec; 11(1):216-220
• Contact Point Address:
  Sean A. P. Clouston, Department of Family, Population, and Preventive Medicine, Program in Public Health, Stony Brook University, Stony Brook, NY
• Email:
  sean.clouston@stonybrookmedicine.edu
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9a2b48ddd2789dceb009ab6cc0a3f9eee8b0c22021dec2f09a3e02e41775fa9dd0699a63e63e16d3a7d3a6413620064f20f41f50772e29f54821b30188faf2a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/207233/cdc_207233_DS1.pdf
• File Type:
  [PDF - 230.35 KB ]