Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers

Details

• Personal Author:
  Asensio C ; Butler-Dawson J ; Dally M ; Griffin BR ; Johnson RJ ; Krisher L ; Lemery J ; Newman, Lee S. ; Sorensen CJ ; Tenney L
• Description:
  OBJECTIVE: Identify early biomarkers and mechanisms of acute kidney injury in workers at risk of developing chronic kidney disease of unknown origin (CKDu). METHODS: We assessed cross-shift changes in kidney function and biomarkers of injury in 105 healthy sugarcane workers. We obtained pre-harvest clinical data as well as daily environmental, clinical, and productivity data for each worker. RESULTS: The average percent decline in cross-shift eGFR was 21.8% (SD 13.6%). Increasing wet bulb globe temperature, high uric acid, decreased urine pH, urinary leukocyte esterase, and serum hyperosmolality were risk factors for decline in kidney function. CONCLUSIONS: Sugarcane workers with normal kidney function experience recurrent subclinical kidney injury, associated with elevations in biomarkers of injury that suggest exposure to high temperatures and extreme physical demands. Description provided by NIOSH
• Subjects:
  • Agriculture
  • Biomarkers
  • Environmental Exposure
  • Men
  • Occupational Health
  • Risk Assessment
  • Risk Factors
  • Safety
  • Temperature
  • Urine
  More +
• Keywords:
  • Biomarkers
  • Kidneys
  • Kidney function
  • Injuries
  • Workers
  • Work environment
  • Agricultural
  • Agriculture
  • Humans
  • Men
  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  239-250
• Volume:
  61
• Issue:
  3
• NIOSHTIC Number:
  nn:20054991
• Citation:
  J Occup Environ Med 2019 Mar; 61(3):239-250
• Contact Point Address:
  Cecilia J. Sorensen, MD, Academic Office 1, 12631E. 17th Ave, Aurora, CO 80045
• Email:
  Cecilia.Sorensen@UCDenver.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Services
• Performing Organization:
  University of Colorado Denver, Aurora
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260831
• Download URL:
  https://stacks.cdc.gov/view/cdc/217396/cdc_217396_DS1.pdf
• File Type:
  [PDF - 451.68 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0b7efc5949c968abaf121493ed04e18aae43bec20991e1bfa8c71c1e178eeab7786b996fc3880c1f3038182e5d21f2fbdd525c9efe737965a6658bf0396d802