Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers

Details

• Personal Author:
  Asensio C ; Butler-Dawson J ; Dally M ; Griffin BR ; Johnson RJ ; Krisher L ; Lemery J ; Newman, Lee S. ; Sorensen CJ ; Tenney L
• Description:
  OBJECTIVE: Identify early biomarkers and mechanisms of acute kidney injury in workers at risk of developing chronic kidney disease of unknown origin (CKDu). METHODS: We assessed cross-shift changes in kidney function and biomarkers of injury in 105 healthy sugarcane workers. We obtained pre-harvest clinical data as well as daily environmental, clinical, and productivity data for each worker. RESULTS: The average percent decline in cross-shift eGFR was 21.8% (SD 13.6%). Increasing wet bulb globe temperature, high uric acid, decreased urine pH, urinary leukocyte esterase, and serum hyperosmolality were risk factors for decline in kidney function. CONCLUSIONS: Sugarcane workers with normal kidney function experience recurrent subclinical kidney injury, associated with elevations in biomarkers of injury that suggest exposure to high temperatures and extreme physical demands. [Description provided by NIOSH]
• Subjects:
  Agriculture Biomarkers Environmental Exposure Men Occupational Health Risk Assessment Risk Factors Safety Temperature Urine Women Workplace

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• Keywords:
  Agricultural Author Keywords: Agricultural Workers Chronic Kidney Disease Environmental Exposure Exposure Levels Global Health Humans Injuries Kidney Function Kidneys Physiological Effects Prevention Risk Factors Statistical Analysis Temperature Effects Urine Chemistry Work Environment Workers

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  239-250
• Volume:
  61
• Issue:
  3
• NIOSHTIC Number:
  nn:20054991
• Citation:
  J Occup Environ Med 2019 Mar; 61(3):239-250
• Contact Point Address:
  Cecilia J. Sorensen, MD, Academic Office 1, 12631E. 17th Ave, Aurora, CO 80045
• Email:
  Cecilia.Sorensen@UCDenver.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Services
• Performing Organization:
  University of Colorado Denver, Aurora
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0b7efc5949c968abaf121493ed04e18aae43bec20991e1bfa8c71c1e178eeab7786b996fc3880c1f3038182e5d21f2fbdd525c9efe737965a6658bf0396d802
• Download URL:
  https://stacks.cdc.gov/view/cdc/217396/cdc_217396_DS1.pdf
• File Type:
  [PDF - 451.68 KB ]