Non-Malignant Respiratory Disease Among Workers in the Rubber Manufacturing Industry: A Systematic Review and Meta-Analysis

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Nett, Randall J. ; Thapa N ; Tomasi, Suzanne E.
• Description:
  Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD. Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Results: We analyzed 62 articles. We identified 11 cases of NMRD. Nine (30%) of 30 cross-sectional studies and one (4%) of 26 mortality studies had strong evidence. The summary odds ratio andSMRfor the cross-sectional and mortality meta-analyses were 3.83 (95% confidence interval [CI], 2.28-6.51) and 0.90 (95%CI, 0.82-0.99), respectively. Conclusion: Available evidence supports rubber manufacturing emissions as a potential risk factor for NMRD-related morbidity. Further investigations with longer follow-up periods and inclusion of short-tenured workers could further define risks for NMRD and identify prevention strategies. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Occupational Health Respiratory System Respiratory Tract Diseases Rubber Safety
• Keywords:
  Author Keywords: Chronic Bronchitis Bronchitis Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Diseases COPD Emphysema Eosinophilia Nonmalignant Respiratory Disease Occupational Asthma Occupational Lung Disease Respiratory Diseases Rubber Rubber Manufacturing Industry Rubber Products Rubber Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-384
• Volume:
  62
• Issue:
  5
• NIOSHTIC Number:
  nn:20054827
• Citation:
  Am J Ind Med 2019 May; 62(5):367-384
• Contact Point Address:
  Suzanne E. Tomasi, DVM, MPH, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS-2800, Morgantown, West Virginia 26505-2888
• Email:
  yxc4@cdc.gov
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:25a5c770ca77162c0a4f06b204e9fd7c98b81b59c3118f6bb471a978cc6aebed5af9ecdad22f1a55fc04bf46d5a514587b3056bab6a8e2d9092892abc75a28d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/217249/cdc_217249_DS1.pdf
• File Type:
  [PDF - 250.60 KB ]