Non-malignant respiratory disease among workers in the rubber manufacturing industry: A systematic review and meta-analysis

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Thapa, Nirmala ; Tomasi, Suzanne E. ; Cox-Ganser, Jean M. ; Nett, Randall J.
• Description:
  Background:
  
  Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD.
  
  Methods:
  
  From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses.
  
  Results:
  
  We analyzed 62 articles. We identified 11 cases of NMRD. Nine (30%) of 30 cross-sectional studies and one (4%) of 26 mortality studies had strong evidence. The summary odds ratio and SMR for the cross-sectional and mortality meta-analyses were 3.83 (95% confidence interval [CI], 2.28–6.51) and 0.90 (95%CI, 0.82–0.99), respectively.
  
  Conclusion:
  
  Available evidence supports rubber manufacturing emissions as a potential risk factor for NMRD-related morbidity. Further investigations with longer follow-up periods and inclusion of short-tenured workers could further define risks for NMRD and identify prevention strategies.
  
  
• Subjects:
  Humans Manufacturing Industry Occupational Diseases Occupational Exposure Respiration Disorders Rubber
• Keywords:
  Chronic Bronchitis Chronic Obstructive Pulmonary Diseases Emphysema Eosinophilia Non-malignant Respiratory Disease Occupational Asthma Occupational Lung Disease Rubber
• Source:
  Am J Ind Med. 62(5):367-384
• Pubmed ID:
  30775791
• Pubmed Central ID:
  PMC6693673
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  62
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:eb191bcc714dd57aa40296c47da764cc41e432f41ed42a5574e5caed992b4bf3f33bde6c8e8810df96e99362549024a565ac948fd6aa235b43e09f38e4edf39d
• Download URL:
  https://stacks.cdc.gov/view/cdc/80731/cdc_80731_DS1.pdf
• File Type:
  [PDF - 439.56 KB ]