Details:

Alternative Title:
Am J Ind Med
Personal Author:
Thapa, Nirmala; Tomasi, Suzanne E.; Cox-Ganser, Jean M.; Nett, Randall J.;
Thapa, Nirmala; Tomasi, Suzanne E.; Cox-Ganser, Jean M.; Nett, Randall J.; Less -
Description:
Background: Non-malignant respiratory disease (NMRD) cases have occurred among rubber manufacturing workers. We examined exposure to rubber manufacturing emissions as a risk factor for NMRD. Methods: From a systematic literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (strong, intermediate, non-significant positive association, none) between exposure to rubber manufacturing emissions and NMRD-related morbidity and mortality, and conducted two meta-analyses. Results: We analyzed 62 articles. We identified 11 cases of NMRD. Nine (30%) of 30 cross-sectional studies and one (4%) of 26 mortality studies had strong evidence. The summary odds ratio and SMR for the cross-sectional and mortality meta-analyses were 3.83 (95% confidence interval [CI], 2.28–6.51) and 0.90 (95%CI, 0.82–0.99), respectively. Conclusion: Available evidence supports rubber manufacturing emissions as a potential risk factor for NMRD-related morbidity. Further investigations with longer follow-up periods and inclusion of short-tenured workers could further define risks for NMRD and identify prevention strategies.
Subject:
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Article
Chronic Bronchitis
Chronic Obstructive Pulmonary Diseases
Emphysema
Eosinophilia
Non-malignant Respiratory Disease
Occupational Asthma
Occupational Lung Disease
Rubber

Source:
Am J Ind Med. 62(5):367-384;
Pubmed ID:
30775791
Pubmed Central ID:
PMC6693673
Document Type:
Journal Article;
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:96c4b12db5d2d230fb0cd325dd356e690e07c7cb8ca6396f750ff22014e9725d
File Type:

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