Contributions of Inhalation and Dermal Exposure to Chlorpyrifos Dose in Egyptian Cotton Field Workers

Details

• Personal Author:
  Farahat FM ; Fenske EK ; Fenske RA ; Galvin K ; Olson JR
• Description:
  Objective: Chlorpyrifos exposures were assessed in 12 Egyptian cotton field workers. Methods: 3,5,6-trichloro-2-pyridinol (TCPy) was measured in 24-hour urine samples to estimate absorbed dose. Workshift air samples were used to calculate chlorpyrifos inhalation dose. Results: Patches on legs had the highest chlorpyrifos loading rates among body regions sampled. Geometric mean chlorpyrifos air concentrations were 5·1, 8·2, and 45·0 ug/m3 for engineers, technicians, and applicators, respectively; peak TCPy urinary concentrations were 75-129, 78-261, and 487-1659 ug/l, respectively; geometric mean doses were 5·2-5·4, 8·6-9·7, and 50-57 ug/kg, respectively, considering TCPy excretion half-life values of 27 and 41 hours. All worker doses exceeded the acceptable operator exposure level of 1·5 ug/kg/day. An estimated 94-96% of the dose was attributed to dermal exposure, calculated as the difference between total dose and inhalation dose. Discussion: Interventions to reduce dermal exposure are warranted in this population, particularly for the hands, feet, and legs. [Description provided by NIOSH]
• Subjects:
  Agriculture Insecticides Musculoskeletal System Occupational Exposure Occupational Health Organophosphates Safety Skin
• Keywords:
  Application Author Keywords: Pesticide Chlorpyrifos Dermal Exposure Egypt Exposure Assessment Inhalation Exposure Lower Extremities Occupational Occupational Exposure Organophosphorus Pesticides Skin Exposure TCPy Upper Extremities Urinary Metabolites Worker

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• ISSN:
  1077-3525
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Louisiana ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 6 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  198-209
• Volume:
  18
• Issue:
  3
• NIOSHTIC Number:
  nn:20054707
• Citation:
  Int J Occup Environ Health 2012 Jul-Sep; 18(3):198-209
• Contact Point Address:
  Richard A. Fenske, Box 357234, University of Washington, Seattle, WA 98195, USA
• Email:
  rfenske@uw.edu
• CAS Registry Number:
  3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Chlorpyrifos (CAS RN 2921-88-2)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Occupational and Environmental Health
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0d28d72199713669c9022cc439bb5e22d6caca0898ecc6b7d86a57c76d764680cd57bea0e41907106376463d0a8f9067ca9edb2968450c61d63833518b4db86e
• Download URL:
  https://stacks.cdc.gov/view/cdc/217157/cdc_217157_DS1.pdf
• File Type:
  [PDF - 751.63 KB ]