Prospective Study of Particulate Air Pollution Exposures, Subclinical Atherosclerosis, and Clinical Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)

Details

• Personal Author:
  Adar SD ; Allen RW ; Barr RG ; Budoff MJ ; Burke GL ; Casillas AM ; Cohen MA ; Curl CL ; Daviglus ML ; Jacobs DR Jr. ; Kaufman JD ; Kronmal RA ; Larson TV ; Liu SL ; Lumley T ; Navas-Acien A ; O'Leary DH ; Rotter JI ; Roux AVD ; Sampson PD ; Sheppard L ; Siscovick DS ; Stein JH ; Szpiro AA ; Tracy RP
• Description:
  The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical atherosclerosis and the incidence of cardiovascular disease (CVD). MESA Air builds on a multicenter, community-based US study of CVD, supplementing that study with additional participants, outcome measurements, and state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, and black carbon. More than 7,000 participants aged 45-84 years are being followed for over 10 years for the identification and characterization of CVD events, including acute myocardial infarction and other coronary artery disease, stroke, peripheral artery disease, and congestive heart failure; cardiac procedures; and mortality. Subcohorts undergo baseline and follow-up measurements of coronary artery calcium using computed tomography and carotid artery intima-medial wall thickness using ultrasonography. This cohort provides vast exposure heterogeneity in ranges currently experienced and permitted in most developed nations, and the air monitoring and modeling methods employed will provide individual estimates of exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Morbidity Mortality Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Atherosclerosis Author Keywords: Air Pollution Cardiovascular Disease Cardiovascular Diseases Cohort Studies Environmental Exposure Epidemiologic Methods Exposure Assessment Morbidity Rates Mortality Rates Particulate Matter Particulates

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Illinois ; Michigan ; Minnesota ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Vermont ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  176
• Issue:
  9
• NIOSHTIC Number:
  nn:20054672
• Citation:
  Am J Epidemiol 2012 Nov; 176(9):825-837
• Contact Point Address:
  Dr. Joel D. Kaufman, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Suite 302, Seattle, WA 98105
• Email:
  joel@u.washington.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:70f6837a68bf1737db29f47fcc68c08c4aa4b7d20ed29f8f8db64c18366c608dd84c4d67c2a0e786358e5c972c3fdc2ca266a3a7b654e3e5ca0b79cc37d14a05
• Download URL:
  https://stacks.cdc.gov/view/cdc/217136/cdc_217136_DS1.pdf
• File Type:
  [PDF - 340.49 KB ]