Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kugelman, Jeffrey R. ; Johnston, Sara C. ; Mulembakani, Prime M. ; Kisalu, Neville ; Lee, Michael S. ; Koroleva, Galina ; McCarthy, Sarah E. ; Gestole, Marie C. ; Wolfe, Nathan D. ; Fair, Joseph N. ; Schneider, Bradley S. ; Wright, Linda L. ; Huggins, John ; Whitehouse, Chris A. ; Wemakoy, Emile Okitolonda ; Muyembe-Tamfum, Jean Jacques ; Hensley, Lisa E. ; Palacios, Gustavo F. ; Rimoin, Anne W.
• Description:
  Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.
• Subjects:
  Amino Acid Sequence Animals Epidemiological Monitoring Gene Deletion Genome, Viral Genomic Instability Humans Molecular Sequence Data Monkeypox Virus Mpox (monkeypox) Phylogeny Sequence Analysis, DNA Severity Of Illness Index

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• Source:
  Emerg Infect Dis. 20(2):232-239.
• Document Type:
  Journal Article
• Place as Subject:
  Democratic Republic of the Congo
• Volume:
  20
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:866f47d145d3837a617841fa71f96e8d9bd1f7889dfe619c61bb74aaf22e5463
• Download URL:
  https://stacks.cdc.gov/view/cdc/21707/cdc_21707_DS1.pdf
• File Type:
  [PDF - 552.18 KB ]