Stability of Monkeypox Virus in Body Fluids and Wastewater

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Yinda, Claude Kwe ; Morris, Dylan H. ; Fischer, Robert J. ; Gallogly, Shane ; Weishampel, Zachary A. ; Port, Julia R. ; Bushmaker, Trenton ; Schulz, Jonathan E. ; Bibby, Kyle ; van Doremalen, Neeltje ; Lloyd-Smith, James O. ; Munster, Vincent J.
• Description:
  An outbreak of human mpox infection in nonendemic countries appears to have been driven largely by transmission through body fluids or skin-to-skin contact during sexual activity. We evaluated the stability of monkeypox virus (MPXV) in different environments and specific body fluids and tested the effectiveness of decontamination methodologies. MPXV decayed faster at higher temperatures, and rates varied considerably depending on the medium in which virus was suspended, both in solution and on surfaces. More proteinaceous fluids supported greater persistence. Chlorination was an effective decontamination technique, but only at higher concentrations. Wastewater was more difficult to decontaminate than plain deionized water; testing for infectious MPXV could be a helpful addition to PCR-based wastewater surveillance when high levels of viral DNA are detected. Our findings suggest that, because virus stability is sufficient to support environmental MPXV transmission in healthcare settings, exposure and dose-response will be limiting factors for those transmission routes.
• Subjects:
  Body Fluids DNA, Viral Humans Monkeypox Virus Wastewater Wastewater-Based Epidemiological Monitoring
• Keywords:
  Body Fluids Human Monkeypox Virus Mpox Sexually Transmitted Infections Surfaces United States Viruses Virus Stability
• Source:
  Emerg Infect Dis. 2023; 29(10):2065-2072
• Pubmed ID:
  37735747
• Pubmed Central ID:
  PMC10521604
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4fd7ebbb4b2961b4168e85b872b3f777aab01f58215645fba4d875b6001c8971
• Download URL:
  https://stacks.cdc.gov/view/cdc/134753/cdc_134753_DS1.pdf
• File Type:
  [PDF - 1.82 MB ]