Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort

Details

• Personal Author:
  Baccarelli A ; Chahine T ; Gold DR ; Litonjua A ; Schwartz J ; Sparrow D ; Suh H ; Vokonas P ; Wright RO
• Description:
  BACKGROUND AND OBJECTIVES: We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 microm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sectional analysis of the Normative Aging Study, an elderly cohort. We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter. METHODS: HRV measurements were taken on 539 subjects. Linear mixed effects models were fit for the logarithm of HRV metrics-including standard deviation of normal-to-normal intervals (SDNN), high frequency (HF), and low frequency (LF)-and PM(2.5) concentrations in the 48 hr preceding HRV measurement, controlling for confounders and a random subject effect. RESULTS: PM(2.5) was significantly associated with SDNN (p = 0.04) and HF (p = 0.03) in all subjects. There was no association in subjects with GSTM1, whereas there was a significant association with SDNN, HF, and LF in subjects with the deletion. Similarly, there was no association with any HRV measure in subjects with the short repeat variant of HMOX-1, and significant associations in subjects with any long repeat. We found a significant three-way interaction of PM(2.5) with GSTM1 and HMOX-1 determining SDNN (p = 0.008), HF (p = 0.01) and LF (p = 0.04). In subjects with the GSTM1 deletion and the HMOX-1 long repeat, SDNN decreased by 13% [95% confidence interval (CI), -21% to -4%], HF decreased by 28% (95% CI, -43% to -9%), and LF decreased by 20% (95% CI, -35% to -3%) per 10 microg/m(3) increase in PM. CONCLUSIONS: Oxidative stress is an important pathway for the autonomic effects of particles. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollution Cardiovascular System Cohort Studies Genetics Men Occupational Health Particulate Matter Safety
• Keywords:
  Age Groups Air Particles Air Pollution Author Keywords: GST Cardiovascular Health Cohort Studies Genes Genetic Variation Health Effects Heart Rate Heart Rate Variability HMOX-1 Humans Models Oxidative Stress Particulates PM2.5

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  115
• Issue:
  11
• NIOSHTIC Number:
  nn:20054477
• Citation:
  Environ Health Perspect 2007 Nov; 115(11):1617-1622
• Contact Point Address:
  J. Schwartz, Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, 401 Park Dr., Suite 415 W, PO Box 15698, Boston, MA 02215
• Email:
  jschwrtz@hsph.harvard.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9e83d983ab4ca9bc820929b693edcc291aa8dc0360513b0475856c13e7a550c8bf8d896a1eb3c6bc775e824f0d9fee23be973904453dd0efaf059f2334da308c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217034/cdc_217034_DS1.pdf
• File Type:
  [PDF - 156.73 KB ]