Particulate Air Pollution, Metabolic Syndrome, and Heart Rate Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)

Details

• Personal Author:
  Auchincloss AH ; Barr RG ; Correa JC ; Diez Roux AV ; Kaufman JD ; Keeler J ; O'Neill MS ; Park SK ; Prineas R
• Description:
  Background: Cardiac autonomic dysfunction has been suggested as a possible biologic pathway for the association between fine particulate matter ≤ 2.5 um in diameter (PM2.5) and cardiovascular disease (CVD). We examined the associations of PM2.5 with heart rate variability, a marker of autonomic function, and whether metabolic syndrome (MetS) modified these associations. Methods: We used data from the Multi-Ethnic Study of Atherosclerosis to measure the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences (rMSSD) of 5,465 participants 45-84 years old who were free of CVD at the baseline examination (2000-2002). Data from the U.S. regulatory monitor network were used to estimate ambient PM2.5 concentrations at the participants' residences. MetS was defined as having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Results: After controlling for confounders, we found that an interquartile range (IQR) increase in 2-day average PM2.5 (10.2 ug/m3) was associated with a 2.1% decrease in rMSSD [95% confidence interval (CI), -4.2 to 0.0] and nonsignificantly associated with a 1.8% decrease in SDNN (95% CI, -3.7 to 0.1). Associations were stronger among individuals with MetS than among those without MetS: an IQR elevation in 2-day PM2.5 was associated with a 6.2% decrease in rMSSD (95% CI, -9.4 to -2.9) among participants with MetS, whereas almost no change was found among participants without MetS (p-interaction = 0.005). Similar effect modification was observed in SDNN (p-interaction = 0.011). Conclusion: These findings suggest that autonomic dysfunction may be a mechanism through which PM exposure affects cardiovascular risk, especially among persons with MetS. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Author Keywords: Air Pollution Autonomic Nervous System Cardiovascular Disease Cohort Studies Health Effects Heart Rate Heart Rate Variability Metabolic Disorders Metabolic Syndrome Particulates PM2.5

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; New York ; North Carolina ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  118
• Issue:
  10
• NIOSHTIC Number:
  nn:20054880
• Citation:
  Environ Health Perspect 2010 Oct; 118(10):1406-1411
• Contact Point Address:
  S.K. Park, SPH II-M6240, Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109 USA
• Email:
  sungkyun@umich.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a18f02ee5d9732ab88ff35221f33ea236c14e8ffbe126188987c649fe3aff97713161fc1cddf0574181457c461297c6796d87fd7af8499321c294fecb31e7628
• Download URL:
  https://stacks.cdc.gov/view/cdc/217294/cdc_217294_DS1.pdf
• File Type:
  [PDF - 249.88 KB ]