Associations of Cumulative Exposure to Heavy Metal Mixtures with Obesity and Its Comorbidities Among U.S. Adults in NHANES 2003–2014

Details

• Personal Author:
  Mukherjee B ; Park SK ; Wang X ; Mukherjee B ; Park SK ; Wang X
• Description:
  Background: Some heavy metals (e.g., arsenic, cadmium, lead, mercury) have been associated with obesity and obesity comorbidities. The analytical approach for those associations has typically focused on individual metals. There is a growing interest in evaluating the health effects of cumulative exposure to metal mixtures. Objectives: We utilized our Environmental Risk Score (ERS), a summary measure to examine the risk of exposure to multi-pollutants in epidemiologic research, to evaluate the associations of cumulative exposure to a mixture of correlated heavy metals with obesity and its comorbidities including hypertension, and type-2 diabetes mellitus (T2DM) while accounting for high degree correlations and interactions among metal mixtures components. Methods: We examined blood and urinary markers of 18 heavy metals among 9537 adults in NHANES 2003-2014. We randomly split data into a training set for the construction of ERS (n=6675) and a testing set for the evaluation of its statistical performance (n=2862). ERS of heavy metal mixtures was computed for waist circumference using adaptive elastic-net (AENET) with 189 predictors including 18 main effects, 18 squared terms, and 153 pairwise interactions of heavy metals. Regression analyses with complex survey designs were performed to assess the associations of ERS with other obesity measures, hypertension and T2DM. Results: 7 main effects (blood lead, blood cadmium, blood mercury, and urinary markers of monomethylarsonic acid (MMA), barium, mercury and thallium), 4 squared terms (blood cadmium, urinary cadmium, urinary antimony and urinary tungsten), and 7 pairwise interactions (blood lead & urinary cadmium, blood lead & urinary MMA, blood lead & urinary uranium, urinary cadmium & urinary MMA, urinary dimethylarsinic acid (DMA) & urinary tungsten, urinary MMA & urinary cobalt, and urinary lead & urinary antimony) were selected by AENET for construction of ERS of waist circumference-related metal mixtures. An increase in ERS from 10th percentile to 90th percentile in the overall study population was significantly associated with 4.50 kg/m2 (95% CI: 4.06, 4.94) higher BMI, 4.16 mm (95% CI: 3.56, 4.76) higher skinfold thickness, and 4.11 kg (95% CI: 0.83, 7.40) higher total body fat, independent of age, sex, race/ethnicity, education, smoking status, physical activity and NHANES cycle (Ps < 0.05). Significant associations of ERS with both hypertension and T2DM were also observed (Ps < 0.05). Conclusions: Our study suggests that cumulative exposure to heavy metals as mixtures is associated with obesity and its related chronic conditions such as hypertension and T2DM. Additional research is needed to confirm these findings in longitudinal settings. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Cardiovascular Diseases Cardiovascular System Environmental Exposure Epidemiology Hematologic Diseases Metals, Heavy Occupational Exposure Occupational Health Safety

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• Keywords:
  Author Keywords: Heavy Metals Blood Sugar Disorders Chronic Exposure Environmental Exposure Heavy Metals Hypertension Mixtures Obesity Obesity-related Comorbidities Weight Factors
• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  121
• NIOSHTIC Number:
  nn:20054206
• Citation:
  Environ Int 2018 Dec; 121(Pt 1):683-694
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan, M5541 SPH II, 1415 Washington Heights, Ann Arbor, MI 48109-2029, United States of America
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Cadmium (CAS RN 7440-43-9) ; Lead (CAS RN 7439-92-1) ; Mercury (CAS RN 7439-97-6) ; Arsenic (CAS RN 7440-38-2) ; Cadmium (CAS RN 7440-43-9) ; Lead (CAS RN 7439-92-1) ; Mercury (CAS RN 7439-97-6)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Part Number:
  1
• Start Date:
  20050701
• Source Full Name:
  Environment International
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7b7d56e60cb14f8ebc7b11df6f3b0b5442b17c5c0d2303d655cd46b6cfb46cdbcd82c3f4b412a7a6d5c2bea79b0ce0b2285965459a4f3a2d7adfbbe7480c2ff2
• Download URL:
  https://stacks.cdc.gov/view/cdc/216818/cdc_216818_DS1.pdf
• File Type:
  [PDF - 925.82 KB ]