Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach – New York City, 2016–2017

Details

• Personal Author:
  Boshuizen V ; Chiu, Sophia ; Crossa A ; Fry AM ; Gould LH ; Gross L ; Harper S ; Havers FP ; Lee CT ; Levine MZ ; Li Z-N ; Liu F ; Poirot E ; Pompey JM ; Rakeman JL ; Russell K ; Slavinski S ; Stewart RJ
• Description:
  Background: In 2016, an influenza A(H7N2) virus outbreak occurred in cats in New York City's municipal animal shelters. One human infection was initially detected. Methods: We conducted a serological survey using a novel approach to rule out cross-reactive antibodies to other seasonal influenza viruses to determine whether additional A(H7N2) human infections had occurred and to assess exposure risk. Results: Of 121 shelter workers, one had serological evidence of A(H7N2) infection, corresponding to a seroprevalence of 0.8% (95% confidence interval, .02%-4.5%). Five persons exhibited low positive titers to A(H7N2) virus, indicating possible infection; however, we could not exclude cross-reactive antibody responses to seasonal influenza viruses. The remaining 115 persons were seronegative. The seropositive person reported multiple direct cat exposures without using personal protective equipment and mild illness with subjective fever, runny nose, and sore throat. Conclusions: We identified a second case of A(H7N2) infection from this outbreak, providing further evidence of cat-to-human transmission of A(H7N2) virus. [Description provided by NIOSH]
• Subjects:
  Animals Antibodies Communicable Diseases Influenza, Human Occupational Health Safety Viral Diseases
• Keywords:
  Animal Handlers Antibody Response Author Keywords: Influenza Avian Influenza Disease Incidence Disease Transmission Exposure Assessment H7N2 Human Infection Humans Infection Control Infectious Diseases Influenza Outbreak Risk Assessment Seasonal Flu Seasonal Influenza Serological Techniques Serology Viral Diseases Viral Infections Zoonoses Zoonotic

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• ISSN:
  0022-1899
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; New York ; Ohio ; Oklahoma ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  219
• Issue:
  11
• NIOSHTIC Number:
  nn:20053777
• Citation:
  J Infect Dis 2019 Jun; 219(11):1688-1696
• Contact Point Address:
  Eugenie Poirot, PhD, MPH, New York City Department of Health and Mental Hygiene, 42-09 28th St, Queens, NY 11101
• Email:
  epoirot@health.nyc.gov
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  The Journal of Infectious Diseases
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6cf838041b2b4d8915086529f61cc1197642e7d59d9ba97c8a84e087d302f41bd9880f42f24e1c0f327828af0c3ea0a180466bf406c36fc93bc0b957ef6a0c79
• Download URL:
  https://stacks.cdc.gov/view/cdc/216481/cdc_216481_DS1.pdf
• File Type:
  [PDF - 608.71 KB ]