Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection
Published Date:Jul 2013
Source:Emerg Infect Dis. 19(7):1138-1141.
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Molecular Diagnostic Techniques
Multilocus Sequence Typing
Tuberculosis And Other Mycobacteria
Description:Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.
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