Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection

Hingley-Wilson, Suzanne M.; Casey, Rosalyn; Connell, David; Bremang, Samuel; Evans, Jason T.; Hawkey, Peter M.; Smith, Grace E.; Jepson, Annette; Philip, Stuart; Kon, Onn Min; Lalvani, Ajit

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Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection

Published Date:

Jul 2013

Source:

Emerg Infect Dis. 19(7):1138-1141.

[PDF-410.62 KB]

Details:

Personal Authors:

Hingley-Wilson, Suzanne M. ; Casey, Rosalyn ; Connell, David ; Bremang, Samuel ; Evans, Jason T. ; ... More ▼

Keywords:

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Description:

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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