Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hingley-Wilson, Suzanne M. ; Casey, Rosalyn ; Connell, David ; Bremang, Samuel ; Evans, Jason T. ; Hawkey, Peter M. ; Smith, Grace E. ; Jepson, Annette ; Philip, Stuart ; Kon, Onn Min ; Lalvani, Ajit
• Description:
  Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.
• Subjects:
  Aged Antimicrobial Resistance Antitubercular Agents Bacteria Co-infection Coinfection Culture Techniques Delayed Diagnosis Dispatch Drug Resistance, Multiple, Bacterial Drug Sensitive Drug Therapy, Combination Ethambutol Humans Isoniazid Male Minisatellite Repeats Molecular Diagnostic Techniques Multidrug Resistant Multilocus Sequence Typing Mycobacterium Tuberculosis TB Treatment Outcome Treatment Resistance Tuberculosis, Multidrug-Resistant Tuberculosis, Pulmonary Tuberculosis And Other Mycobacteria

  More +
• Source:
  Emerg Infect Dis. 19(7):1138-1141.
• Document Type:
  Journal Article
• Volume:
  19
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:feb6d102514fb6fd8828bdd0ede3052f634f795d621222c6d9fc9ec6f0d96982
• Download URL:
  https://stacks.cdc.gov/view/cdc/21630/cdc_21630_DS1.pdf
• File Type:
  [PDF - 410.62 KB ]