Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure

Details

• Personal Author:
  Fan Q ; Li Y ; Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells EM ; Zheng W ; Zhou J ; Zhou Y
• Description:
  Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI16) and total work history (MnCEITOT). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEITOT and MnCEI16 were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) microg/L, 13.5 (58.5) microg/g, and 2.6 (7.2) microg/g dry bone, respectively. MnCEI16 was significantly correlated with FMn (Spearman's r = 0.44; p = 0.02), BnMn (r = 0.44; p < 0.01), and MnCEITOT (r = 0.44; p < 0.01). In adjusted regression models, MnCEI16 was significantly associated with BnMn (beta = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Blood Demography Education Environmental Exposure Hematologic Tests Manganese Men Nervous System Occupational Exposure Occupational Health Safety Surveys And Questionnaires

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• Keywords:
  Age Factors Author Keywords: Manganese Blood Analysis Blood Manganese Blood Samples Bone Manganese Bone Structure Cross Sectional Studies Cumulative Exposure Index Demographic Characteristics Employee Exposure Exposure Assessment Exposure Levels Fingernail Manganese Humans In Vivo Neutron Activation Analysis Mass Spectrometry Models Neurotoxicology Parkinsonism Questionnaires Regression Analysis

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; Indiana ; Louisiana ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  7
• NIOSHTIC Number:
  nn:20053535
• Citation:
  Int J Environ Res Public Health 2018 Jul; 15(7):1341
• Contact Point Address:
  Ellen M. Wells, School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
• Email:
  wells54@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7625fd7184600199cc4bf727ae863c5c8354fdceedee7bf04b4645ca0abc569f46d5d17cd1201c51573ee3914c398d0e733768d5e61fbb79ed6e27f6df10eb4a
• Download URL:
  https://stacks.cdc.gov/view/cdc/216268/cdc_216268_DS1.pdf
• File Type:
  [PDF - 703.72 KB ]