The Association of Bone, Fingernail and Blood Manganese with Cognitive and Olfactory Function in Chinese Workers

Details

• Personal Author:
  Fan Q ; Li Y ; Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells EM ; Zauber SE ; Zheng W ; Zhou Y
• Description:
  Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. BMn and FMn were measured using inductively coupled plasma mass spectrometry. Cognitive and olfactory function was assessed using Animal and Fruit Naming tests, World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test (AVLT) and the University of Pennsylvania Smell Identification Test (UPSIT). Additional data were obtained via questionnaire. Regression models adjusted for age, education, factory of employment, and smoking status (UPSIT only), were used to assess the relationship between Mn biomarkers and test scores. In adjusted models, increasing BnMn was significantly associated with decreased performance on average AVLT scores [beta (95% confidence interval (CI)) = -0.65 (-1.21, -0.09)] and Animal Naming scores [beta (95% CI) = -1.54 (-3.00, -0.07)]. Increasing FMn was significantly associated with reduced performance measured by the average AVLT [beta (95% CI) = -0.35 (-0.70, -0.006)] and the difference in AVLT scores [beta (95% CI) = -0.40 (-0.77, -0.03)]. BMn was not significantly associated with any test scores; no significant associations were observed with Fruit Naming or UPSIT tests. BnMn and FMn, but not BMn, are associated with cognitive function in Mn-exposed workers. None of the biomarkers were significantly associated with olfactory function. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Hematologic Tests Manganese Nervous System Occupational Exposure Occupational Health Safety Surveys And Questionnaires
• Keywords:
  Analytical Methods Auditory System Author Keywords: Manganese Biological Systems Biomarker Blood Samples Bone Structure Brain Function Brain Matter Cognitive Function Cross Sectional Studies Employee Exposure Exposure Assessment Humans In Vivo Study Mass Spectrometry Neurotoxicology Neutron Activation Analysis Olfactory Function Olfactory System Parkinsonism Performance Capability Performance Tests Questionnaires Regression Analysis Speech Transmission Workers

  More +
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; Florida ; Georgia ; Indiana ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  666
• NIOSHTIC Number:
  nn:20055451
• Citation:
  Sci Total Environ 2019 May; 666:1003-1010
• Contact Point Address:
  Ellen M. Wells, School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA
• Email:
  wells54@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2019
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  Science of the Total Environment
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e0d1b35e49483c88566147a7ba3bfec33d0d37475adc31abd13da790024e6664a9039e2bfd10fc6fc7bc19419d97d9cba45251260a41569b5da8a9857ae73d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/213297/cdc_213297_DS1.pdf
• File Type:
  [PDF - 403.54 KB ]